2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-nitrophenyl acetamide

Base Information

Chemical Name:2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-nitrophenyl acetamide
CAS No.:1562665-08-0
Molecular Formula:C₂₄H₂₂N₄O₃S
Molecular Weight:446.53
Hs Code.:

Synonyms:2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-nitrophenyl acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-nitrophenyl acetamide

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Technology Process of 2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-nitrophenyl acetamide

There total 5 articles about 2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-nitrophenyl acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 10147-70-3
2-chloro-N-(2-nitrophenyl)acetamide

: 1562664-70-3
1-(3,5-dimethylbenzyl)-1,3-dihydro-2H-benzo[d]imidazole-2-thione

: 1562665-08-0
2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-nitrophenyl acetamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2013.12.045

Reference yield:

: 88-74-4
2-nitro-aniline

: 1562665-08-0
2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-nitrophenyl acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.12.045

Reference yield:

: 27129-86-8
1-bromomethyl-3,5-dimethylbenzene

: 1562665-08-0
2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-nitrophenyl acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2: hydrogenchloride; zinc / ethanol / 1 h / Reflux

3: pyridine / 1 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; sodium hydride; potassium carbonate; zinc; In pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.12.045