(E)-2-(5-fluoro-1-((4'-fluoro-[1,1'-biphenyl]-4-yl)methylene)-1H-inden-3-yl)acetic acid

Base Information

Chemical Name:(E)-2-(5-fluoro-1-((4'-fluoro-[1,1'-biphenyl]-4-yl)methylene)-1H-inden-3-yl)acetic acid
CAS No.:1361000-87-4
Molecular Formula:C₂₄H₁₆F₂O₂
Molecular Weight:374.387
Hs Code.:

Synonyms:(E)-2-(5-fluoro-1-((4'-fluoro-[1,1'-biphenyl]-4-yl)methylene)-1H-inden-3-yl)acetic acid

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Chemical Property of (E)-2-(5-fluoro-1-((4'-fluoro-[1,1'-biphenyl]-4-yl)methylene)-1H-inden-3-yl)acetic acid

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Technology Process of (E)-2-(5-fluoro-1-((4'-fluoro-[1,1'-biphenyl]-4-yl)methylene)-1H-inden-3-yl)acetic acid

There total 3 articles about (E)-2-(5-fluoro-1-((4'-fluoro-[1,1'-biphenyl]-4-yl)methylene)-1H-inden-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1361001-59-3
sodium (E)-2-(5-fluoro-1-((4'-fluoro-[1,1'-biphenyl]-4-yl)methylene)-1H-inden-3-yl)acetate

: 1361000-87-4
(E)-2-(5-fluoro-1-((4'-fluoro-[1,1'-biphenyl]-4-yl)methylene)-1H-inden-3-yl)acetic acid

Guidance literature:: With hydrogenchloride; In water; at 20 ℃;
DOI:10.1021/jm201528b

Reference yield:

: 1481-32-9
6-fluoroindan-1-one

: 1361000-87-4
(E)-2-(5-fluoro-1-((4'-fluoro-[1,1'-biphenyl]-4-yl)methylene)-1H-inden-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -75 °C / Inert atmosphere

1.2: 2 h / -75 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid; calcium chloride / toluene / 16 h / Reflux

2.2: 20 - 70 °C

2.3: 20 °C / pH 1 - 2

3.1: hydrogenchloride / water / 20 °C

With hydrogenchloride; toluene-4-sulfonic acid; calcium chloride; lithium diisopropyl amide; In tetrahydrofuran; water; toluene;
DOI:10.1021/jm201528b

Reference yield:

: 162548-68-7
ethyl 2-(6-fluoro-1-hydroxy-2,3-dihydro-1H-inden-1-yl)acetate

: 1361000-87-4
(E)-2-(5-fluoro-1-((4'-fluoro-[1,1'-biphenyl]-4-yl)methylene)-1H-inden-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid; calcium chloride / toluene / 16 h / Reflux

1.2: 20 - 70 °C

1.3: 20 °C / pH 1 - 2

2.1: hydrogenchloride / water / 20 °C

With hydrogenchloride; toluene-4-sulfonic acid; calcium chloride; In water; toluene;
DOI:10.1021/jm201528b