(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-amino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Base Information

• Chemical Name: (+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-amino)propyl]-N⁶-(4-monomethoxytrityl)-adenine
• CAS No.: 889885-76-1
• Molecular Formula: C₃₆H₄₅N₆O₅P
• Molecular Weight: 672.764

Synonyms:(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-amino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Chemical Property of (+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-amino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-amino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

There total 6 articles about (+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-amino)propyl]-N⁶-(4-monomethoxytrityl)-adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-azido)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-75-0) → (+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-amino)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-76-1)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 14h;

DOI:10.1080/15257770500265315

Reference yield:

(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-hydroxy)-propyl]-N6-(4-monomethoxytrityl)-adenine (889885-74-9) → (+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-amino)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-76-1)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 20 h / 20 °C

2: 458 mg / NaN₃ / dimethylformamide / 4 h / 100 °C

3: 85 percent / PPh₃; H₂O / tetrahydrofuran / 14 h / 20 °C

With pyridine; sodium azide; water; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1080/15257770500265315

Reference yield:

methanesulfonic acid 4-(diisopropoxy-phosphorylmethoxy)-3-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-butyl ester → (+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-amino)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 458 mg / NaN₃ / dimethylformamide / 4 h / 100 °C

2: 85 percent / PPh₃; H₂O / tetrahydrofuran / 14 h / 20 °C

With sodium azide; water; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1080/15257770500265315

upstream raw materials:

(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-azido)propyl]-N⁶-(4-monomethoxytrityl)-adenine

(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-hydroxy)-propyl]-N⁶-(4-monomethoxytrityl)-adenine

(+/-)-9-[(1-hydroxymethyl)(3-(4-monomethoxytrityl)oxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

(+/-)-9-[1-[(diisopropylphosphono)methoxymethyl](3-(4-monomethoxytrityl)oxy)-propyl]-N⁶-(4-monomethoxytrityl)-adenine

Downstream raw materials:

(+/-)-9-[1-(phosphonomethoxy)methyl][3-(4-monomethoxytritylamino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

(+/-)-9-[1-[(di-isopropyloxycarbonyloxymethylphosphonomethoxy)methyl](3-(4-monomethyxytrityl)amino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-(4-monomethoxytrityl)amino)propyl]-N⁶-(4-monomethoxytrityl)-adenine

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