8-(1-{2-oxo-2-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Base Information

Chemical Name:8-(1-{2-oxo-2-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione
CAS No.:1188543-09-0
Molecular Formula:C₃₃H₄₂F₃N₇O₅Si
Molecular Weight:701.821
Hs Code.:

8-(1-{2-oxo-2-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Synonyms:8-(1-{2-oxo-2-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

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Chemical Property of 8-(1-{2-oxo-2-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

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Technology Process of 8-(1-{2-oxo-2-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

There total 3 articles about 8-(1-{2-oxo-2-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 869788-45-4
1,3-dipropyl-8-(1H-pyrazol-4-yl)-7-(2-trimethylsilanylethoxymethyl)-3,7-dihydro-purine-2,6-dione

: 1188543-08-9
4-(2-bromoacetyl)-1-(3-trifluoromethylphenyl)pyrrolidin-2-one

: 1188543-09-0
8-(1-{2-oxo-2-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Guidance literature:: With caesium carbonate; In acetonitrile; at 90 - 100 ℃; for 6h;

Reference yield:

: 2357-26-8
5-oxo-1-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid

: 1188543-09-0
8-(1-{2-oxo-2-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.1: acetonitrile / 1 h / 20 °C

2.2: 0 - 20 °C

3.1: caesium carbonate / acetonitrile / 6 h / 90 - 100 °C

With thionyl chloride; caesium carbonate; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;

Reference yield:

: 38124-10-6
C₁₂H₉ClF₃NO₂

: 1188543-09-0
8-(1-{2-oxo-2-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile / 1 h / 20 °C

1.2: 0 - 20 °C

2.1: caesium carbonate / acetonitrile / 6 h / 90 - 100 °C

With caesium carbonate; In acetonitrile;