methyl 7-(4-((4-chlorophenethyl)carbamoyl)phenoxy)-6-cyanochroman-4-carboxylate

Base Information

Chemical Name:methyl 7-(4-((4-chlorophenethyl)carbamoyl)phenoxy)-6-cyanochroman-4-carboxylate
CAS No.:1202889-77-7
Molecular Formula:C₂₇H₂₃ClN₂O₅
Molecular Weight:490.943
Hs Code.:

Synonyms:methyl 7-(4-((4-chlorophenethyl)carbamoyl)phenoxy)-6-cyanochroman-4-carboxylate

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Chemical Property of methyl 7-(4-((4-chlorophenethyl)carbamoyl)phenoxy)-6-cyanochroman-4-carboxylate

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Technology Process of methyl 7-(4-((4-chlorophenethyl)carbamoyl)phenoxy)-6-cyanochroman-4-carboxylate

There total 5 articles about methyl 7-(4-((4-chlorophenethyl)carbamoyl)phenoxy)-6-cyanochroman-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1009102-40-2
N-[2-(4-chlorophenyl)ethyl]-4-hydroxy benzamide

: 1202889-76-6
methyl 6-cyano-7-fluorochroman-4-carboxylate

: 1202889-77-7
methyl 7-(4-((4-chlorophenethyl)carbamoyl)phenoxy)-6-cyanochroman-4-carboxylate

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 6h; Inert atmosphere;

Reference yield:

: 113209-68-0
3,4-dihydro-7-fluoro-2H-1-benzopyran-4-one

: 1202889-77-7
methyl 7-(4-((4-chlorophenethyl)carbamoyl)phenoxy)-6-cyanochroman-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: zinc(II) iodide / 4 h / 20 °C

2: hydrogenchloride; tin(II) chloride dihdyrate / water; acetic acid / 130 °C

3: sulfuric acid / tetrahydrofuran / 12 h / 55 °C

4: N-Bromosuccinimide / N,N-dimethyl-formamide / 2.5 h / 50 °C

5: 1-methyl-pyrrolidin-2-one / 6 h / 160 °C / Inert atmosphere

6: potassium carbonate / 1-methyl-pyrrolidin-2-one / 6 h / 110 °C / Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; tin(II) chloride dihdyrate; sulfuric acid; potassium carbonate; zinc(II) iodide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1202889-73-3
7-fluoro-3,4-dihydro-2H-chromene-4-carboxylic acid

: 1202889-77-7
methyl 7-(4-((4-chlorophenethyl)carbamoyl)phenoxy)-6-cyanochroman-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / tetrahydrofuran / 12 h / 55 °C

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 2.5 h / 50 °C

3: 1-methyl-pyrrolidin-2-one / 6 h / 160 °C / Inert atmosphere

4: potassium carbonate / 1-methyl-pyrrolidin-2-one / 6 h / 110 °C / Inert atmosphere

With N-Bromosuccinimide; sulfuric acid; potassium carbonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;