(S)-(6-(4-bromophenyl)-4-hydroxy-3,4-dihydropyridin-1(2H)-yl)(phenyl)methanone

Base Information

• Chemical Name: (S)-(6-(4-bromophenyl)-4-hydroxy-3,4-dihydropyridin-1(2H)-yl)(phenyl)methanone
• CAS No.: 1378530-15-4
• Molecular Formula: C₁₈H₁₆BrNO₂
• Molecular Weight: 358.235

Synonyms:(S)-(6-(4-bromophenyl)-4-hydroxy-3,4-dihydropyridin-1(2H)-yl)(phenyl)methanone

Chemical Property of (S)-(6-(4-bromophenyl)-4-hydroxy-3,4-dihydropyridin-1(2H)-yl)(phenyl)methanone

Chemical Property:

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Technology Process of (S)-(6-(4-bromophenyl)-4-hydroxy-3,4-dihydropyridin-1(2H)-yl)(phenyl)methanone

There total 1 articles about (S)-(6-(4-bromophenyl)-4-hydroxy-3,4-dihydropyridin-1(2H)-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C18H16BrNO2 (1378530-29-0) → (S)-(6-(4-bromophenyl)-4-hydroxy-3,4-dihydropyridin-1(2H)-yl)(phenyl)methanone (1378530-15-4)

Guidance literature:

With [(R)-BINOL-Ti(OiPr)2]3; In dichloromethane; at -30 ℃; for 40h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201200459

Reference yield:

(S)-(6-(4-bromophenyl)-4-hydroxy-3,4-dihydropyridin-1(2H)-yl)(phenyl)methanone (1378530-15-4) → C18H15BrN4O + C18H15BrN4O

Guidance literature:

With diphenyl phosphorazidate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 0 - 20 ℃; for 18h; Overall yield = 81 %; Inert atmosphere;

DOI:10.1055/s-0037-1610384

upstream raw materials:

C₁₈H₁₆BrNO₂

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