5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4,5-naphtho[1,2-c]isoxazole

Base Information

Chemical Name:5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4,5-naphtho[1,2-c]isoxazole
CAS No.:1307813-85-9
Molecular Formula:C₂₃H₁₃F₅N₂O₂
Molecular Weight:444.36
Hs Code.:

Synonyms:5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4,5-naphtho[1,2-c]isoxazole

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Chemical Property of 5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4,5-naphtho[1,2-c]isoxazole

Chemical Property:

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Technology Process of 5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4,5-naphtho[1,2-c]isoxazole

There total 13 articles about 5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4,5-naphtho[1,2-c]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.7%

: 1307813-84-8
5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-naphtho[1,2-c]isoxazol-7-yl trifluoromethanesulfonate

: 7486-35-3
tri-n-butyl(vinyl)tin

: 1307813-85-9
5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4,5-naphtho[1,2-c]isoxazole

Guidance literature:: With lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 20 - 100 ℃;

Reference yield:

: 7063-99-2
ethyl 5-phenylisoxazole-3-carboxylate

: 1307813-85-9
5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4,5-naphtho[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 10 steps

1.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

3.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

3.2: pH 1

4.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran / 0.37 h / 0 °C

5.2: 0.58 h / 0 °C

5.3: 20 °C

6.1: tert.-butylhydroperoxide / copper(l) iodide / N,N-dimethyl-formamide; acetonitrile / 20 - 50 °C

7.1: diethylamino-sulfur trifluoride / 1,2-dichloro-ethane / 24 h / 20 - 60 °C

8.1: boron tribromide / dichloromethane / 0 - 20 °C

9.1: pyridine / 0 - 20 °C

10.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 20 - 100 °C

With pyridine; tert.-butylhydroperoxide; N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; lithium hydroxide monohydrate; diethylamino-sulfur trifluoride; boron tribromide; trifluoroacetic acid; lithium chloride; lithium diisopropyl amide; diazomethyl-trimethyl-silane; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 536-74-3
phenylacetylene

: 1307813-85-9
5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4,5-naphtho[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethylamine / diethyl ether / 3 h / 20 °C

2.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

3.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

4.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

4.2: pH 1

5.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran / 0.37 h / 0 °C

6.2: 0.58 h / 0 °C

6.3: 20 °C

7.1: tert.-butylhydroperoxide / copper(l) iodide / N,N-dimethyl-formamide; acetonitrile / 20 - 50 °C

8.1: diethylamino-sulfur trifluoride / 1,2-dichloro-ethane / 24 h / 20 - 60 °C

9.1: boron tribromide / dichloromethane / 0 - 20 °C

10.1: pyridine / 0 - 20 °C

11.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 20 - 100 °C

With pyridine; tert.-butylhydroperoxide; N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; lithium hydroxide monohydrate; diethylamino-sulfur trifluoride; boron tribromide; triethylamine; trifluoroacetic acid; lithium chloride; lithium diisopropyl amide; diazomethyl-trimethyl-silane; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;