2,2-di-tert-butyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-7-methylene-hexahydro-1,3,5-trioxa-2-sila-benzocycloheptene

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Chemical Name:2,2-di-tert-butyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-7-methylene-hexahydro-1,3,5-trioxa-2-sila-benzocycloheptene
CAS No.:440635-10-9
Molecular Formula:C₃₃H₅₀O₄Si₂
Molecular Weight:566.929
Hs Code.:

2,2-di-<i>tert</i>-butyl-6-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-7-methylene-hexahydro-1,3,5-trioxa-2-sila-benzocycloheptene

Synonyms:2,2-di-tert-butyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-7-methylene-hexahydro-1,3,5-trioxa-2-sila-benzocycloheptene

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Chemical Property of 2,2-di-tert-butyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-7-methylene-hexahydro-1,3,5-trioxa-2-sila-benzocycloheptene

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Technology Process of 2,2-di-tert-butyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-7-methylene-hexahydro-1,3,5-trioxa-2-sila-benzocycloheptene

There total 11 articles about 2,2-di-tert-butyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-7-methylene-hexahydro-1,3,5-trioxa-2-sila-benzocycloheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 440635-09-6
2,2-di-tert-butyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-1,3,5-trioxa-2-sila-benzocyclohepten-7-one

: 440635-10-9
2,2-di-tert-butyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-7-methylene-hexahydro-1,3,5-trioxa-2-sila-benzocycloheptene

Guidance literature:: In tetrahydrofuran; toluene; at 0 ℃; for 0.583333h;
DOI:10.1016/S0040-4020(02)00038-8

Reference yield:

: 391235-59-9
(4S,5R)-2,2-di-tert-butyl-5-hydroxy-1,3-dioxa-2-silacyclohexane-4-methanol

: 440635-10-9
2,2-di-tert-butyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-7-methylene-hexahydro-1,3,5-trioxa-2-sila-benzocycloheptene

Guidance literature:: Multi-step reaction with 10 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

2.1: 2.59 g / 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

3.1: 91 percent / HMPA; n-BuLi / tetrahydrofuran; hexane / 0.67 h / -100 °C

4.1: 98 percent / TsOH*H₂O / methanol / 2 h / 20 °C

5.1: 97 percent / MgBr₂*Et₂O / CH₂Cl₂ / 1 h / 20 °C

6.1: 83 percent / DBU / CH₂Cl₂ / 1 h / 0 °C

7.1: H₂ / 20 percent Pd(OH)2/C / ethyl acetate / 1 h

8.1: 1.26 g / imidazole / dimethylformamide / 3 h / 20 °C

9.1: BF₃*OEt₂; molecular sieves 3 Angstroem / CH₂Cl₂; hexane / 0.33 h / -78 °C

9.2: 72 percent / PPTS / methanol / 4 h / 20 °C

10.1: 95 percent / tetrahydrofuran; toluene / 0.58 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 3 A molecular sieve; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; magnesium bromide; palladium dihydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(02)00038-8

Reference yield:

: 391235-78-2
(1S,6R,8S)-8-(benzyloxy)methyl-3,3-di-tert-butyl-2,4,7-trioxa-3-silabicyclo[4.4.0]deca-9-one

: 440635-10-9
2,2-di-tert-butyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-7-methylene-hexahydro-1,3,5-trioxa-2-sila-benzocycloheptene

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂ / 20 percent Pd(OH)2/C / ethyl acetate / 1 h

2.1: 1.26 g / imidazole / dimethylformamide / 3 h / 20 °C

3.1: BF₃*OEt₂; molecular sieves 3 Angstroem / CH₂Cl₂; hexane / 0.33 h / -78 °C

3.2: 72 percent / PPTS / methanol / 4 h / 20 °C

4.1: 95 percent / tetrahydrofuran; toluene / 0.58 h / 0 °C

With 1H-imidazole; 3 A molecular sieve; boron trifluoride diethyl etherate; hydrogen; palladium dihydroxide; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(02)00038-8