(5S)-1(S)-(benzyloxy)-3(S)-<((2-methoxyethoxy)methyl)oxy>-4(S),6(R)-dimethyl-8-oxabicyclo<3.3.1>nonane

Base Information

Chemical Name:(5S)-1(S)-(benzyloxy)-3(S)-<((2-methoxyethoxy)methyl)oxy>-4(S),6(R)-dimethyl-8-oxabicyclo<3.3.1>nonane
CAS No.:112321-21-8
Molecular Formula:C₂₁H₃₂O₅
Molecular Weight:364.482
Hs Code.:

Synonyms:(5S)-1(S)-(benzyloxy)-3(S)-<((2-methoxyethoxy)methyl)oxy>-4(S),6(R)-dimethyl-8-oxabicyclo<3.3.1>nonane

Suppliers and Price of (5S)-1(S)-(benzyloxy)-3(S)-<((2-methoxyethoxy)methyl)oxy>-4(S),6(R)-dimethyl-8-oxabicyclo<3.3.1>nonane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5S)-1(S)-(benzyloxy)-3(S)-<((2-methoxyethoxy)methyl)oxy>-4(S),6(R)-dimethyl-8-oxabicyclo<3.3.1>nonane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5S)-1(S)-(benzyloxy)-3(S)-<((2-methoxyethoxy)methyl)oxy>-4(S),6(R)-dimethyl-8-oxabicyclo<3.3.1>nonane

There total 10 articles about (5S)-1(S)-(benzyloxy)-3(S)-<((2-methoxyethoxy)methyl)oxy>-4(S),6(R)-dimethyl-8-oxabicyclo<3.3.1>nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112347-67-8
6(R)-1(S),7(R)-dimethyl-2(S)-bromo-4(R)-(2-propenyl)-9-oxabicyclo<4.3.0>nonane

: 112321-21-8
(5S)-1(S)-(benzyloxy)-3(S)-<((2-methoxyethoxy)methyl)oxy>-4(S),6(R)-dimethyl-8-oxabicyclo<3.3.1>nonane

Guidance literature:: Multi-step reaction with 8 steps

1: O₃ / CH₂Cl₂ / 0.2 h / -78 °C

2: acetic anhydride, Et₃N, (N,N-dimethylamino)pyridine / CH₂Cl₂ / 16 h / 40 °C

3: 87 percent / zinc / ethanol; H₂O / 16 h / Heating

4: 99 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 5 h

5: 100 percent / LAH / diethyl ether / 2 h / 0 °C

6: 91 percent / oxalyl chloride, DMSO, Et₃N / CH₂Cl₂ / 0.25 h / -50 °C

8: 1.) KH / 1.) THF, RT, 10 min, 2.) RT, 90 min

With dmap; lithium aluminium tetrahydride; oxalyl dichloride; pyridinium p-toluenesulfonate; acetic anhydride; potassium hydride; ozone; dimethyl sulfoxide; triethylamine; zinc; In diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jo00238a030

Reference yield:

: 112321-00-3,112419-70-2
2-((1R,5S)-5-Isopropenyl-2-methyl-cyclohex-2-enyl)-propan-1-ol

: 112321-21-8
(5S)-1(S)-(benzyloxy)-3(S)-<((2-methoxyethoxy)methyl)oxy>-4(S),6(R)-dimethyl-8-oxabicyclo<3.3.1>nonane

Guidance literature:: Multi-step reaction with 9 steps

1: 85 percent / N-bromosuccinimide / acetone / 0.25 h / 0 °C

2: O₃ / CH₂Cl₂ / 0.2 h / -78 °C

3: acetic anhydride, Et₃N, (N,N-dimethylamino)pyridine / CH₂Cl₂ / 16 h / 40 °C

4: 87 percent / zinc / ethanol; H₂O / 16 h / Heating

5: 99 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 5 h

6: 100 percent / LAH / diethyl ether / 2 h / 0 °C

7: 91 percent / oxalyl chloride, DMSO, Et₃N / CH₂Cl₂ / 0.25 h / -50 °C

9: 1.) KH / 1.) THF, RT, 10 min, 2.) RT, 90 min

With dmap; N-Bromosuccinimide; lithium aluminium tetrahydride; oxalyl dichloride; pyridinium p-toluenesulfonate; acetic anhydride; potassium hydride; ozone; dimethyl sulfoxide; triethylamine; zinc; In diethyl ether; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jo00238a030

Reference yield:

: 112347-68-9
1-((3R,3aR,5R,7S,7aS)-7-Bromo-3,7a-dimethyl-octahydro-benzofuran-5-yl)-1-methoxy-eth-1-yl-hydroperoxide

: 112321-21-8
(5S)-1(S)-(benzyloxy)-3(S)-<((2-methoxyethoxy)methyl)oxy>-4(S),6(R)-dimethyl-8-oxabicyclo<3.3.1>nonane

Guidance literature:: Multi-step reaction with 7 steps

1: acetic anhydride, Et₃N, (N,N-dimethylamino)pyridine / CH₂Cl₂ / 16 h / 40 °C

2: 87 percent / zinc / ethanol; H₂O / 16 h / Heating

3: 99 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 5 h

4: 100 percent / LAH / diethyl ether / 2 h / 0 °C

5: 91 percent / oxalyl chloride, DMSO, Et₃N / CH₂Cl₂ / 0.25 h / -50 °C

7: 1.) KH / 1.) THF, RT, 10 min, 2.) RT, 90 min

With dmap; lithium aluminium tetrahydride; oxalyl dichloride; pyridinium p-toluenesulfonate; acetic anhydride; potassium hydride; dimethyl sulfoxide; triethylamine; zinc; In diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jo00238a030