3-[(tert-butoxycarbonyl)amino]-4-phenylbutanaldehyde

Base Information

• Chemical Name: 3-[(tert-butoxycarbonyl)amino]-4-phenylbutanaldehyde
• CAS No.: 130944-47-7
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.337
• Mol file: 130944-47-7.mol

Synonyms:3-[(tert-butoxycarbonyl)amino]-4-phenylbutanaldehyde

Chemical Property of 3-[(tert-butoxycarbonyl)amino]-4-phenylbutanaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-[(tert-butoxycarbonyl)amino]-4-phenylbutanaldehyde

There total 14 articles about 3-[(tert-butoxycarbonyl)amino]-4-phenylbutanaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1,1-dimethylethyl [(1S)-3-hydroxy-1-(phenylmethyl)propyl]carbamate (94670-70-9) → 3-[(tert-butoxycarbonyl)amino]-4-phenylbutanaldehyde (130944-47-7)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -60 ℃; for 0.833333h;

DOI:10.1021/jm00038a005

Reference yield: 75.0%

methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-4-phenylbutanoate (60398-42-7,142854-48-6) → 3-[(tert-butoxycarbonyl)amino]-4-phenylbutanaldehyde (130944-47-7)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; hexane; at -78 ℃; for 1h;

DOI:10.1021/jm00382a008

Reference yield: 72.0%

(S)-3-<(tert-butoxycarbonyl)amino>-4-phenylbutanenitrile (172695-25-9) → 3-[(tert-butoxycarbonyl)amino]-4-phenylbutanaldehyde (130944-47-7)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; toluene; at -60 ℃; for 7.5h;

upstream raw materials:

(S)-3-tert-butoxycarbonylamino-4-phenylbutanoic acid

methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-4-phenylbutanoate

1,1-dimethylethyl [(1S)-3-hydroxy-1-(phenylmethyl)propyl]carbamate

(S)-3-<(tert-butoxycarbonyl)amino>-4-phenylbutanenitrile

Downstream raw materials:

(E)-(R)-5-tert-Butoxycarbonylamino-2-methyl-6-phenyl-hex-2-enoic acid methyl ester

N-<3-<(tert-butoxycarbonyl)amino>-1-carboxamido-4-phenylbut>-Ala-Pro-OCH3

N-(3-benzamido-1-carboxy-4-phenylbutyl)-Ala-Pro

N-(3-benzamido-1-carboxamido-4-phenylbutyl)-Ala-Pro-OCH₃