8-acetyl-5-(2-chlorophenyl)-3-methyl-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>diazepine-2-one

Base Information

Chemical Name:8-acetyl-5-(2-chlorophenyl)-3-methyl-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>diazepine-2-one
CAS No.:130311-72-7
Molecular Formula:C₁₉H₁₈ClN₃O₂S
Molecular Weight:387.89
Hs Code.:

Synonyms:8-acetyl-5-(2-chlorophenyl)-3-methyl-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>diazepine-2-one

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Chemical Property of 8-acetyl-5-(2-chlorophenyl)-3-methyl-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>diazepine-2-one

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Technology Process of 8-acetyl-5-(2-chlorophenyl)-3-methyl-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>diazepine-2-one

There total 5 articles about 8-acetyl-5-(2-chlorophenyl)-3-methyl-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>diazepine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130311-71-6
6-acetyl-2-(2-aminopropionylamino)-3-(2-chlorobenzoyl)-4,5,6,7-tetrahydro-thieno[2,3-C]pyridine

: 130311-72-7
8-acetyl-5-(2-chlorophenyl)-3-methyl-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>diazepine-2-one

Guidance literature:: With pyridine; acetic acid; In toluene; for 24h; Yield given; Heating;
DOI:10.1248/cpb.39.3215

Reference yield:

: 32161-06-1
1-acetyl-4-piperidinone

: 130311-72-7
8-acetyl-5-(2-chlorophenyl)-3-methyl-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>diazepine-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / S, Et₃N / dimethylformamide / 1 h / 60 °C

2: 95 percent / NaHCO₃ / toluene; H₂O / 60 °C

3: liquid NH₃ / 1,2-dichloro-ethane; ethyl acetate / 1 h / 100 °C

4: pyridine, AcOH / toluene / 24 h / Heating

With pyridine; ammonia; sodium hydrogencarbonate; acetic acid; triethylamine; In water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.39.3215

Reference yield:

: 40018-25-5
2-Chlorobenzoyl acetonitrile

: 130311-72-7
8-acetyl-5-(2-chlorophenyl)-3-methyl-6,7,8,9-tetrahydro-1H,3H-pyrido<4',3':4,5>thieno<3,2-f><1,4>diazepine-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / S, Et₃N / dimethylformamide / 1 h / 60 °C

2: 95 percent / NaHCO₃ / toluene; H₂O / 60 °C

3: liquid NH₃ / 1,2-dichloro-ethane; ethyl acetate / 1 h / 100 °C

4: pyridine, AcOH / toluene / 24 h / Heating

With pyridine; ammonia; sodium hydrogencarbonate; acetic acid; triethylamine; In water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.39.3215