(R)-1-[(S)-1-phenylethyl]-2-trifluoromethylaziridine

Base Information

• Chemical Name: (R)-1-[(S)-1-phenylethyl]-2-trifluoromethylaziridine
• CAS No.: 198019-17-9
• Molecular Formula: C₁₁H₁₂F₃N
• Molecular Weight: 215.218
• Mol file: 198019-17-9.mol

Synonyms:(R)-1-[(S)-1-phenylethyl]-2-trifluoromethylaziridine

Chemical Property of (R)-1-[(S)-1-phenylethyl]-2-trifluoromethylaziridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-[(S)-1-phenylethyl]-2-trifluoromethylaziridine

There total 3 articles about (R)-1-[(S)-1-phenylethyl]-2-trifluoromethylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

(S)-1-((S)-1-phenylethylamino)-3,3,3-trifluoro-2-propanol (198019-16-8) → (R)-1-[(S)-1-phenylethyl]-2-trifluoromethylaziridine (198019-17-9)

Guidance literature:

With chloro(triphenyl)phosphonium chloride; triethylamine; In acetonitrile; for 3h; Heating;

DOI:10.1016/S0957-4166(97)00320-0

Reference yield:

(β-trifluoromethyl)vinyl diphenylsulfonium trifluoromethanesulfonate (1228046-56-7) + (S)-1-phenyl-ethylamine (2627-86-3) → (S)-1-[(S)-1-phenylethyl]-2-trifluoromethylaziridine (1228046-60-3) + (R)-1-[(S)-1-phenylethyl]-2-trifluoromethylaziridine (198019-17-9)

Guidance literature:

With tert-butylamine; In dimethyl sulfoxide; at 20 ℃; for 2.5h; optical yield given as %de; Inert atmosphere;

DOI:10.1021/ol100768s

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → (R)-1-[(S)-1-phenylethyl]-2-trifluoromethylaziridine (198019-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / acetonitrile / Ambient temperature

2: 24 percent / Ph₃PCl₂, Et₃N / acetonitrile / 3 h / Heating

With dichlorotriphenyl-λ⁴-phosphane; triethylamine; In acetonitrile;

DOI:10.1016/S0957-4166(97)00320-0

upstream raw materials:

(S)-1-((S)-1-phenylethylamino)-3,3,3-trifluoro-2-propanol

(S)-1-phenyl-ethylamine

(β-trifluoromethyl)vinyl diphenylsulfonium trifluoromethanesulfonate

Downstream raw materials:

(R)-2-((S)-1-phenylethylamino)-3,3,3-trifluoro-1-propanol