{2-Chloro-3-methoxy-5-[(E)-2-methyl-4-(triphenyl-λ⁵-phosphanylidene)-but-2-enyl]-phenyl}-methyl-carbamic acid methyl ester

Base Information

• Chemical Name: {2-Chloro-3-methoxy-5-[(E)-2-methyl-4-(triphenyl-λ⁵-phosphanylidene)-but-2-enyl]-phenyl}-methyl-carbamic acid methyl ester
• CAS No.: 82599-04-0
• Molecular Formula: C₃₃H₃₃ClNO₃P
• Molecular Weight: 558.057

Synonyms:{2-Chloro-3-methoxy-5-[(E)-2-methyl-4-(triphenyl-λ⁵-phosphanylidene)-but-2-enyl]-phenyl}-methyl-carbamic acid methyl ester

Chemical Property of {2-Chloro-3-methoxy-5-[(E)-2-methyl-4-(triphenyl-λ⁵-phosphanylidene)-but-2-enyl]-phenyl}-methyl-carbamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-Chloro-3-methoxy-5-[(E)-2-methyl-4-(triphenyl-λ⁵-phosphanylidene)-but-2-enyl]-phenyl}-methyl-carbamic acid methyl ester

There total 7 articles about {2-Chloro-3-methoxy-5-[(E)-2-methyl-4-(triphenyl-λ⁵-phosphanylidene)-but-2-enyl]-phenyl}-methyl-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{2-Chloro-3-methoxy-5-[(E)-2-methyl-4-(triphenyl-λ5-phosphanyl)-but-2-enyl]-phenyl}-methyl-carbamic acid methyl ester → {2-Chloro-3-methoxy-5-[(E)-2-methyl-4-(triphenyl-λ5-phosphanylidene)-but-2-enyl]-phenyl}-methyl-carbamic acid methyl ester (82599-04-0)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; N,N-dimethyl-formamide; at -63 ℃;

DOI:10.1021/ja00382a065

Reference yield:

(2-Chloro-5-iodomethyl-3-methoxy-phenyl)-methyl-carbamic acid methyl ester (82599-00-6) → {2-Chloro-3-methoxy-5-[(E)-2-methyl-4-(triphenyl-λ5-phosphanylidene)-but-2-enyl]-phenyl}-methyl-carbamic acid methyl ester (82599-04-0)

Guidance literature:

Multi-step reaction with 6 steps

2: ozone / -78 °C

3: NaBH₄ / ethanol / 0.5 h / 0 °C

4: PBr₃, LiBr, collidine / diethyl ether; tetrahydrofuran

5: nitromethane

6: t-BuLi / tetrahydrofuran; dimethylformamide / -63 °C

With 2,3,5-trimethyl-pyridine; sodium tetrahydroborate; tert.-butyl lithium; phosphorus tribromide; ozone; lithium bromide; In tetrahydrofuran; diethyl ether; nitromethane; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ja00382a065

Reference yield:

[2-Chloro-5-((E)-4-hydroxy-2-methyl-but-2-enyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester (67705-16-2) → {2-Chloro-3-methoxy-5-[(E)-2-methyl-4-(triphenyl-λ5-phosphanylidene)-but-2-enyl]-phenyl}-methyl-carbamic acid methyl ester (82599-04-0)

Guidance literature:

Multi-step reaction with 3 steps

1: PBr₃, LiBr, collidine / diethyl ether; tetrahydrofuran

2: nitromethane

3: t-BuLi / tetrahydrofuran; dimethylformamide / -63 °C

With 2,3,5-trimethyl-pyridine; tert.-butyl lithium; phosphorus tribromide; lithium bromide; In tetrahydrofuran; diethyl ether; nitromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja00382a065

upstream raw materials:

{(E)-4-[4-Chloro-3-methoxy-5-(methoxycarbonyl-methyl-amino)-phenyl]-3-methyl-but-2-enyl}-triphenyl-phosphonium; bromide

(2-Chloro-5-iodomethyl-3-methoxy-phenyl)-methyl-carbamic acid methyl ester

[2-Chloro-5-((E)-4-hydroxy-2-methyl-but-2-enyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester

[2-Chloro-3-methoxy-5-((E)-2-methyl-4-oxo-but-2-enyl)-phenyl]-methyl-carbamic acid methyl ester

Downstream raw materials:

{5-[(2E,4E,11E)-(6R,9S,10S)-9-(tert-Butyl-dimethyl-silanyloxy)-6,7,7-trimethoxy-2,10,12-trimethyl-13-oxo-trideca-2,4,11-trienyl]-2-chloro-3-methoxy-phenyl}-methyl-carbamic acid methyl ester

(2E,9E,11E)-(4S,5S,8R)-5-(tert-Butyl-dimethyl-silanyloxy)-13-(4-chloro-3-methoxy-5-methylamino-phenyl)-7,7,8-trimethoxy-2,4,12-trimethyl-trideca-2,9,11-trien-1-ol

{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol

(S)-3-{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-3-hydroxy-propionic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 82599-04-0 {2-Chloro-3-methoxy-5-[(E)-2-methyl-4-(triphenyl-λ⁵-phosphanylidene)-but-2-enyl]-phenyl}-methyl-carbamic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send