1-[[3-(6,7-diamino-3,4-dihydro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

Base Information

Chemical Name:1-[[3-(6,7-diamino-3,4-dihydro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine
CAS No.:791049-17-7
Molecular Formula:C₂₂H₂₈N₆O₄S
Molecular Weight:472.568
Hs Code.:

Synonyms:1-[[3-(6,7-diamino-3,4-dihydro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

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Chemical Property of 1-[[3-(6,7-diamino-3,4-dihydro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

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Technology Process of 1-[[3-(6,7-diamino-3,4-dihydro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

There total 11 articles about 1-[[3-(6,7-diamino-3,4-dihydro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 252233-03-7
1-[[3-(7-amino-3,4-dihydro-6-nitro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

: 791049-17-7
1-[[3-(6,7-diamino-3,4-dihydro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

Guidance literature:: With hydrogen; 10percent Pd/C; at 20 ℃; under 2068.65 Torr;
DOI:10.1021/jm000081+

Reference yield: 50.0%

: 791049-17-7
1-[[3-(6,7-diamino-3,4-dihydro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

Guidance literature:

Reference yield:

: 40928-13-0
4-chloroisatoic anhydride

: 791049-17-7
1-[[3-(6,7-diamino-3,4-dihydro-4-oxo-2-quinazolinyl)propoxyphenyl]sulfonyl]-4-methylpiperazine

Guidance literature:: Multi-step reaction with 8 steps

1: 49 percent / conc. H₂SO₄; conc. HNO₃ / 1 h / 0 °C

2: 86 percent / HOAc; NH₄OAc / 3 h / 100 °C

3: 93 percent / pyridine / dimethylformamide / 2.5 h / 80 °C

4: 89 percent / 30percent aq. H₂O₂; NaOH / ethanol / 2 h / Heating

5: chlorosulfonic acid / 5 h / 0 °C

6: Et₃N / CH₂Cl₂; tetrahydrofuran / 2 h / 20 °C

7: 70 percent / 28percent aq. ammonium hydroxide / ethanol / 140 °C

8: 50 percent / H₂; 10percent aq. HCl / 10percent Pd/C / 20 °C / 2068.65 Torr

With pyridine; chlorosulfonic acid; sodium hydroxide; sulfuric acid; ammonium acetate; hydrogen; nitric acid; acetic acid; triethylamine; 10percent Pd/C; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Nitration / 2: Elimination / 3: Substitution / 4: Cyclization / 5: Substitution / 6: Substitution / 7: Substitution / 8: Catalytic hydrogenation;
DOI:10.1021/jm000081+