4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(hydroxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoic acid hydrochloride

Base Information

Chemical Name:4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(hydroxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoic acid hydrochloride
CAS No.:1312769-44-0
Molecular Formula:C₂₅H₂₈ClN₅O₈*ClH
Molecular Weight:598.44
Hs Code.:

Synonyms:4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(hydroxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoic acid hydrochloride

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Chemical Property of 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(hydroxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoic acid hydrochloride

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Technology Process of 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(hydroxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoic acid hydrochloride

There total 4 articles about 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(hydroxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312771-06-4
tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(hydroxyimino)-7-oxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate

: 1312769-44-0
4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(hydroxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 5.5h;

Reference yield:

: 1312770-25-4
tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-thioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate

: 1312769-44-0
4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(hydroxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; triethylamine; mercury(II) diacetate / tetrahydrofuran; methanol / 3 h / 0 °C

2: hydrogenchloride / ethyl acetate / 5.5 h / 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; mercury(II) diacetate; triethylamine; In tetrahydrofuran; methanol; ethyl acetate;

Reference yield:

: 1312770-12-9
tert-butyl 4-[(1R)-1-isocyanatobutyl]-2-nitrobenzoate

: 1312769-44-0
4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(hydroxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / acetonitrile; tetrahydrofuran / 1 h / Cooling with ice

2: 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides / tetrahydrofuran / 2 h / Cooling with ice

3: hydroxylamine hydrochloride; triethylamine; mercury(II) diacetate / tetrahydrofuran; methanol / 3 h / 0 °C

4: hydrogenchloride / ethyl acetate / 5.5 h / 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; potassium tert-butylate; mercury(II) diacetate; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; triethylamine; In tetrahydrofuran; methanol; ethyl acetate; acetonitrile;