(2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxiranyl)-methanol

Base Information

Chemical Name:(2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxiranyl)-methanol
CAS No.:863782-53-0
Molecular Formula:C₂₄H₃₈O₂Si
Molecular Weight:386.65
Hs Code.:

(2-{3-<i>tert</i>-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxiranyl)-methanol

Synonyms:(2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxiranyl)-methanol

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Chemical Property of (2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxiranyl)-methanol

Chemical Property:

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Technology Process of (2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxiranyl)-methanol

There total 5 articles about (2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxiranyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 863782-52-9
2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-prop-2-en-1-ol

: 863782-53-0
(2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxiranyl)-methanol

: (2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxiranyl)-methanol

Guidance literature:: With titanium(IV) isopropylate; L-(+)-diisopropyl tartrate; 4 A molecular sieve; In tert-butyl alcohol; at -50 - -20 ℃; for 16h; Title compound not separated from byproducts;
DOI:10.1002/anie.200500484

Reference yield:

: 863782-50-7
1-bromo-3-tert-butyl-5-[2-[tris(isopropyl)silyl]ethynyl]benzene

: 863782-53-0
(2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxiranyl)-methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-BuLi / tetrahydrofuran / 0.08 h / -78 °C

1.2: ZnBr₂ / tetrahydrofuran / 0.5 h / -78 - 0 °C

1.3: 99 percent / Pd(Ph₃P)4 / tetrahydrofuran / 16 h / 20 °C

2.1: 79 percent / aq. HCl / tetrahydrofuran / 4 h / 20 °C

3.1: Ti(i-PrO)4; L-DIPT; 4 Angstroem molecular sieves / 2-methyl-propan-2-ol / 16 h / -50 - -20 °C

With titanium(IV) isopropylate; hydrogenchloride; L-(+)-diisopropyl tartrate; 4 A molecular sieve; tert.-butyl lithium; In tetrahydrofuran; tert-butyl alcohol; 3.1: Sharpless epoxidation;
DOI:10.1002/anie.200500484

Reference yield:

: 863782-51-8
1-tert-butyl-3-[1-(tert-butyl-dimethyl-silanyloxymethyl)-vinyl]-5-[(triisopropylsilanyl)-ethynyl]-benzene

: 863782-53-0
(2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxiranyl)-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / aq. HCl / tetrahydrofuran / 4 h / 20 °C

2: Ti(i-PrO)4; L-DIPT; 4 Angstroem molecular sieves / 2-methyl-propan-2-ol / 16 h / -50 - -20 °C

With titanium(IV) isopropylate; hydrogenchloride; L-(+)-diisopropyl tartrate; 4 A molecular sieve; In tetrahydrofuran; tert-butyl alcohol; 2: Sharpless epoxidation;
DOI:10.1002/anie.200500484