(5S,6S)-6-[(1E,3R,4R,6R,9Z)-6-(tert-butyldimethylsiloxy)-3-[2-(tert-butyldiphenylsiloxy)ethyl]-10-cyclohexyl-4-(4-methoxybenzyloxy)-3-(triethylsiloxy)deca-1,9-dien-7-ynyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one

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Chemical Name:(5S,6S)-6-[(1E,3R,4R,6R,9Z)-6-(tert-butyldimethylsiloxy)-3-[2-(tert-butyldiphenylsiloxy)ethyl]-10-cyclohexyl-4-(4-methoxybenzyloxy)-3-(triethylsiloxy)deca-1,9-dien-7-ynyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one
CAS No.:902782-39-2
Molecular Formula:C₆₁H₉₀O₇Si₃
Molecular Weight:1019.64
Hs Code.:

(5S,6S)-6-[(1E,3R,4R,6R,9Z)-6-(tert-butyldimethylsiloxy)-3-[2-(tert-butyldiphenylsiloxy)ethyl]-10-cyclohexyl-4-(4-methoxybenzyloxy)-3-(triethylsiloxy)deca-1,9-dien-7-ynyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one

Synonyms:(5S,6S)-6-[(1E,3R,4R,6R,9Z)-6-(tert-butyldimethylsiloxy)-3-[2-(tert-butyldiphenylsiloxy)ethyl]-10-cyclohexyl-4-(4-methoxybenzyloxy)-3-(triethylsiloxy)deca-1,9-dien-7-ynyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one

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Chemical Property of (5S,6S)-6-[(1E,3R,4R,6R,9Z)-6-(tert-butyldimethylsiloxy)-3-[2-(tert-butyldiphenylsiloxy)ethyl]-10-cyclohexyl-4-(4-methoxybenzyloxy)-3-(triethylsiloxy)deca-1,9-dien-7-ynyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one

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Technology Process of (5S,6S)-6-[(1E,3R,4R,6R,9Z)-6-(tert-butyldimethylsiloxy)-3-[2-(tert-butyldiphenylsiloxy)ethyl]-10-cyclohexyl-4-(4-methoxybenzyloxy)-3-(triethylsiloxy)deca-1,9-dien-7-ynyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one

There total 4 articles about (5S,6S)-6-[(1E,3R,4R,6R,9Z)-6-(tert-butyldimethylsiloxy)-3-[2-(tert-butyldiphenylsiloxy)ethyl]-10-cyclohexyl-4-(4-methoxybenzyloxy)-3-(triethylsiloxy)deca-1,9-dien-7-ynyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 902782-17-6
ethyl (2Z,4S,5S,6E,8R,9R,11R,14Z)-11-(tert-butyldimethylsiloxy)-8-[2-(tert-butyldiphenylsiloxy)ethyl]-15-cyclohexyl-4-ethyl-5-hydroxy-9-(4-methoxybenzyloxy)-8-(triethylsiloxy)pentadeca-2,6,14-trien-12-ynoate

: 902782-39-2
(5S,6S)-6-[(1E,3R,4R,6R,9Z)-6-(tert-butyldimethylsiloxy)-3-[2-(tert-butyldiphenylsiloxy)ethyl]-10-cyclohexyl-4-(4-methoxybenzyloxy)-3-(triethylsiloxy)deca-1,9-dien-7-ynyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one

Guidance literature:: With titanium(IV) isopropylate; In benzene; at 80 ℃; for 0.333333h;
DOI:10.1002/anie.200600458

Reference yield:

: 902782-15-4
ethyl (2R,3S,4E,6R,7R,9R,12Z)-9-(tert-butyldimethylsiloxy)-6-(2-(tert-butyldiphenylsiloxy)ethyl)-13-cyclohexyl-2-ethyl-7-(4-methoxybenzyloxy)-3,6-bis(triethylsiloxy)trideca-4,12-dien-10-ynethioate

: 902782-39-2
(5S,6S)-6-[(1E,3R,4R,6R,9Z)-6-(tert-butyldimethylsiloxy)-3-[2-(tert-butyldiphenylsiloxy)ethyl]-10-cyclohexyl-4-(4-methoxybenzyloxy)-3-(triethylsiloxy)deca-1,9-dien-7-ynyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / toluene; hexane / 0.5 h / -78 °C

2: 2.40 g / Bu₄NOH / tetrahydrofuran; methanol / 6 h / -18 °C

3: 86 percent / pyridinium p-toluenesulfonate / methanol; tetrahydrofuran / 20 °C

4: 94 percent / Ti(O-iPr)4 / benzene / 0.33 h / 80 °C

With titanium(IV) isopropylate; tetra(n-butyl)ammonium hydroxide; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; In tetrahydrofuran; methanol; hexane; toluene; benzene;
DOI:10.1002/anie.200600458

Reference yield:

: 902782-38-1
(2R,3S,4E,6R,7R,9R,12Z)-9-(tert-butyldimethylsiloxy)-6-[2-(tert-butyldiphenylsiloxy)ethyl]-13-cyclohexyl-2-ethyl-7-(4-methoxybenzyloxy)-3,6-bis(triethylsiloxy)trideca-4,12-dien-10-ynal

: 902782-39-2
(5S,6S)-6-[(1E,3R,4R,6R,9Z)-6-(tert-butyldimethylsiloxy)-3-[2-(tert-butyldiphenylsiloxy)ethyl]-10-cyclohexyl-4-(4-methoxybenzyloxy)-3-(triethylsiloxy)deca-1,9-dien-7-ynyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 2.40 g / Bu₄NOH / tetrahydrofuran; methanol / 6 h / -18 °C

2: 86 percent / pyridinium p-toluenesulfonate / methanol; tetrahydrofuran / 20 °C

3: 94 percent / Ti(O-iPr)4 / benzene / 0.33 h / 80 °C

With titanium(IV) isopropylate; tetra(n-butyl)ammonium hydroxide; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; benzene;
DOI:10.1002/anie.200600458