5-Amino-3-phenyl-pentanoic acid [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amide

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Chemical Name:5-Amino-3-phenyl-pentanoic acid [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amide
CAS No.:550312-85-1
Molecular Formula:C₂₁H₂₈N₄O₅
Molecular Weight:416.477
Hs Code.:

Synonyms:5-Amino-3-phenyl-pentanoic acid [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amide

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Chemical Property of 5-Amino-3-phenyl-pentanoic acid [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amide

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Technology Process of 5-Amino-3-phenyl-pentanoic acid [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amide

There total 3 articles about 5-Amino-3-phenyl-pentanoic acid [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 600135-81-7
4-cyano-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-3-phenyl-butyramide

: 550312-85-1
5-Amino-3-phenyl-pentanoic acid [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amide

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 12h;
DOI:10.1016/S0022-328X(02)02100-9

Reference yield:

: 131906-15-5
γ-cyano-3-phenylbutanoic acid

: 550312-85-1
5-Amino-3-phenyl-pentanoic acid [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N'-dicyclohexyl carbodiimide / dimethylformamide / 1.5 h / 50 °C

2: 284 mg / dimethylformamide

3: 98 percent / conc.HCl; hydrogen / 10 percent Pd/C / methanol / 12 h / 20 °C

With hydrogenchloride; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0022-328X(02)02100-9

Reference yield:

: 4-cyano-3-phenyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

: 550312-85-1
5-Amino-3-phenyl-pentanoic acid [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 284 mg / dimethylformamide

2: 98 percent / conc.HCl; hydrogen / 10 percent Pd/C / methanol / 12 h / 20 °C

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0022-328X(02)02100-9