4-((5-carbamoyl-4-((2-fluorobenzyl)amino)pyrimidin-2-yl)amino)phenyl methanesulfonate

Base Information

Chemical Name:4-((5-carbamoyl-4-((2-fluorobenzyl)amino)pyrimidin-2-yl)amino)phenyl methanesulfonate
CAS No.:1430095-71-8
Molecular Formula:C₁₉H₁₈FN₅O₄S
Molecular Weight:431.447
Hs Code.:

Synonyms:4-((5-carbamoyl-4-((2-fluorobenzyl)amino)pyrimidin-2-yl)amino)phenyl methanesulfonate

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Chemical Property of 4-((5-carbamoyl-4-((2-fluorobenzyl)amino)pyrimidin-2-yl)amino)phenyl methanesulfonate

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Technology Process of 4-((5-carbamoyl-4-((2-fluorobenzyl)amino)pyrimidin-2-yl)amino)phenyl methanesulfonate

There total 6 articles about 4-((5-carbamoyl-4-((2-fluorobenzyl)amino)pyrimidin-2-yl)amino)phenyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.9%

: 4-((5-carbamoyl-4-chloropyrimidin-2-yl)amino)phenyl methanesulfonate

: 89-99-6
2-fluorobenzylamine

: 1430095-71-8
4-((5-carbamoyl-4-((2-fluorobenzyl)amino)pyrimidin-2-yl)amino)phenyl methanesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; for 6h; Heating;
DOI:10.1016/j.bioorg.2020.103851

Reference yield:

: 53554-29-3
ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate

: 1430095-71-8
4-((5-carbamoyl-4-((2-fluorobenzyl)amino)pyrimidin-2-yl)amino)phenyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 3-chloro-benzenecarboperoxoic acid / 1,4-dioxane; chloroform / 0.83 h / -2 - 0 °C

2.1: toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / Heating

3.1: lithium hydroxide / water; tetrahydrofuran / Heating

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 1 h / 0 - 26 °C

5.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / Heating

6.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 6 h / Heating

With benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; chloroform; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bioorg.2020.103851

Reference yield:

: 1430097-79-2
ethyl 4-hydroxy-2-((4-((methylsulfonyl)oxy) phenyl)amino)pyrimidine-5-carboxylate

: 1430095-71-8
4-((5-carbamoyl-4-((2-fluorobenzyl)amino)pyrimidin-2-yl)amino)phenyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide / water; tetrahydrofuran / Heating

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 1 h / 0 - 26 °C

3.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / Heating

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 6 h / Heating

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bioorg.2020.103851