3-(4-([3,4'-bipyridin]-2-yloxy)phenyl)-6-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine

Base Information

Chemical Name:3-(4-([3,4'-bipyridin]-2-yloxy)phenyl)-6-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine
CAS No.:1620098-42-1
Molecular Formula:C₂₄H₁₇ClN₄O
Molecular Weight:412.878
Hs Code.:

Synonyms:3-(4-([3,4'-bipyridin]-2-yloxy)phenyl)-6-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine

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Chemical Property of 3-(4-([3,4'-bipyridin]-2-yloxy)phenyl)-6-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine

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Technology Process of 3-(4-([3,4'-bipyridin]-2-yloxy)phenyl)-6-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine

There total 4 articles about 3-(4-([3,4'-bipyridin]-2-yloxy)phenyl)-6-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1214356-68-9
2-fluoro-3,4'-bipyridine

: 1620098-35-2
4-(6-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)phenol

: 1620098-42-1
3-(4-([3,4'-bipyridin]-2-yloxy)phenyl)-6-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide; at 80 ℃; for 12h; Inert atmosphere; Schlenk technique;
DOI:10.1016/j.bmcl.2014.06.028

Reference yield:

: 1190317-85-1
3-bromo-6-chloro-1H-pyrrolo[3,2-b]pyridine

: 1620098-42-1
3-(4-([3,4'-bipyridin]-2-yloxy)phenyl)-6-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere; Schlenk technique

1.2: 1 h / 20 °C / Inert atmosphere; Schlenk technique

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere; Schlenk technique

3.1: caesium carbonate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere; Schlenk technique

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; caesium carbonate; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.06.028

Reference yield:

: 1620098-37-4
3-bromo-6-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine

: 1620098-42-1
3-(4-([3,4'-bipyridin]-2-yloxy)phenyl)-6-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere; Schlenk technique

2: caesium carbonate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere; Schlenk technique

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; caesium carbonate; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.06.028