ethyl 2-((4-chlorophenyl)thio)-4-methyl-6-phenylpyrimidine-5-carboxylate

Base Information

• Chemical Name: ethyl 2-((4-chlorophenyl)thio)-4-methyl-6-phenylpyrimidine-5-carboxylate
• CAS No.: 1421829-30-2
• Molecular Formula: C₂₀H₁₇ClN₂O₂S
• Molecular Weight: 384.886
• Mol file: 1421829-30-2.mol

Synonyms:ethyl 2-((4-chlorophenyl)thio)-4-methyl-6-phenylpyrimidine-5-carboxylate

Chemical Property of ethyl 2-((4-chlorophenyl)thio)-4-methyl-6-phenylpyrimidine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl 2-((4-chlorophenyl)thio)-4-methyl-6-phenylpyrimidine-5-carboxylate

There total 5 articles about ethyl 2-((4-chlorophenyl)thio)-4-methyl-6-phenylpyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

di(4-chlorophenyl)iodonium trifluoromethanesulfonate + 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione (123043-88-9,33458-26-3) → ethyl 2-((4-chlorophenyl)thio)-4-methyl-6-phenylpyrimidine-5-carboxylate (1421829-30-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 12h; Reflux;

DOI:10.1016/j.tetlet.2012.10.131

Reference yield: 75.0%

(4-chlorphenyl)magnesium bromide (873-77-8) + diethyl 2,2′-disulfanediylbis(6-methyl-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate) → ethyl 2-((4-chlorophenyl)thio)-4-methyl-6-phenylpyrimidine-5-carboxylate (1421829-30-2)

Guidance literature:

diethyl 2,2′-disulfanediylbis(6-methyl-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate); With ferrocene; In tetrahydrofuran; for 0.25h; Inert atmosphere; Schlenk technique;

(4-chlorphenyl)magnesium bromide; In tetrahydrofuran; at -20 ℃; for 0.5h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.201400980

Reference yield: 52.0%

p-Chlorothiophenol (106-54-7) + diethyl 2,2′-disulfanediylbis(6-methyl-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate) → ethyl 2-((4-chlorophenyl)thio)-4-methyl-6-phenylpyrimidine-5-carboxylate (1421829-30-2)

Guidance literature:

With potassium phosphate; copper(l) chloride; In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1002/hc.21397

upstream raw materials:

5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione

ethyl acetoacetate

benzaldehyde

(4-chlorphenyl)magnesium bromide