(S)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5,5-difluorohexanoate

Base Information

Chemical Name:(S)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5,5-difluorohexanoate
CAS No.:1581718-77-5
Molecular Formula:C₂₁H₂₇F₂NO₅
Molecular Weight:411.446
Hs Code.:

Synonyms:(S)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5,5-difluorohexanoate

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Chemical Property of (S)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5,5-difluorohexanoate

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Technology Process of (S)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5,5-difluorohexanoate

There total 4 articles about (S)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5,5-difluorohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.9%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1581718-76-4
(S)-4-benzyl-3-(4,4-difluoropentanoyl)oxazolidin-2-one

: 1581718-77-5
(S)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5,5-difluorohexanoate

Guidance literature:: (S)-4-benzyl-3-(4,4-difluoropentanoyl)oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.466667h;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at -78 - 20 ℃; for 0.0833333h;

Reference yield:

: 6939-75-9
benzyl levulinate

: 1581718-77-5
(S)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5,5-difluorohexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 72 h / 0 - 40 °C

2.1: lithium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 20 °C

3.2: -78 - 20 °C / Inert atmosphere

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.47 h / -78 °C

4.2: 0.08 h / -78 - 20 °C

With oxalyl dichloride; diethylamino-sulfur trifluoride; sodium hexamethyldisilazane; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1581718-70-8
benzyl 4,4-difluoropentanoate

: 1581718-77-5
(S)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5,5-difluorohexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 20 °C

2.2: -78 - 20 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.47 h / -78 °C

3.2: 0.08 h / -78 - 20 °C

With oxalyl dichloride; sodium hexamethyldisilazane; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;