1-(tert-butylamino)-2-(dimethylcarbamoyl)-1,3-dioxobutan-2-yl 2-tosylacetate

Base Information

Chemical Name:1-(tert-butylamino)-2-(dimethylcarbamoyl)-1,3-dioxobutan-2-yl 2-tosylacetate
CAS No.:1592250-53-7
Molecular Formula:C₂₀H₂₈N₂O₇S
Molecular Weight:440.518
Hs Code.:

Synonyms:1-(tert-butylamino)-2-(dimethylcarbamoyl)-1,3-dioxobutan-2-yl 2-tosylacetate

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Chemical Property of 1-(tert-butylamino)-2-(dimethylcarbamoyl)-1,3-dioxobutan-2-yl 2-tosylacetate

Chemical Property:

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Technology Process of 1-(tert-butylamino)-2-(dimethylcarbamoyl)-1,3-dioxobutan-2-yl 2-tosylacetate

There total 3 articles about 1-(tert-butylamino)-2-(dimethylcarbamoyl)-1,3-dioxobutan-2-yl 2-tosylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 119072-55-8,7188-38-7
tert-butylisonitrile

: N,N-dimethyl-α,β-dioxobutanamide

: 3937-96-0
tosylacetic acid

: 1592250-53-7
1-(tert-butylamino)-2-(dimethylcarbamoyl)-1,3-dioxobutan-2-yl 2-tosylacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 1.8h; Time; Solvent; regioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201301548

Reference yield:

: 2044-64-6
N,N-Dimethylacetoacetamid

: 1592250-53-7
1-(tert-butylamino)-2-(dimethylcarbamoyl)-1,3-dioxobutan-2-yl 2-tosylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 4-acetamidobenzenesulfonyl azide; triethylamine / acetonitrile / 16 h / 20 °C / Inert atmosphere

2: tert-butylhypochlorite / formic acid / 0 °C / Inert atmosphere

3: dichloromethane / 1.8 h / 20 °C / Inert atmosphere

With tert-butylhypochlorite; 4-acetamidobenzenesulfonyl azide; triethylamine; In formic acid; dichloromethane; acetonitrile; 3: |Passerini Condensation;
DOI:10.1002/ejoc.201301548

Reference yield:

: 2-diazo-3-oxobutyric acid N,N-dimethyl amide

: 1592250-53-7
1-(tert-butylamino)-2-(dimethylcarbamoyl)-1,3-dioxobutan-2-yl 2-tosylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: tert-butylhypochlorite / formic acid / 0 °C / Inert atmosphere

2: dichloromethane / 1.8 h / 20 °C / Inert atmosphere

With tert-butylhypochlorite; In formic acid; dichloromethane; 2: |Passerini Condensation;
DOI:10.1002/ejoc.201301548