[5-formyl-2-(3-nitrooxypropoxy)phenyl]-4-(tert-butoxycarbonylamino)butanoate

Base Information

Chemical Name:[5-formyl-2-(3-nitrooxypropoxy)phenyl]-4-(tert-butoxycarbonylamino)butanoate
CAS No.:1447759-80-9
Molecular Formula:C₁₉H₂₆N₂O₉
Molecular Weight:426.423
Hs Code.:

Synonyms:[5-formyl-2-(3-nitrooxypropoxy)phenyl]-4-(tert-butoxycarbonylamino)butanoate

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Chemical Property of [5-formyl-2-(3-nitrooxypropoxy)phenyl]-4-(tert-butoxycarbonylamino)butanoate

Chemical Property:

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Technology Process of [5-formyl-2-(3-nitrooxypropoxy)phenyl]-4-(tert-butoxycarbonylamino)butanoate

There total 3 articles about [5-formyl-2-(3-nitrooxypropoxy)phenyl]-4-(tert-butoxycarbonylamino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 57294-38-9
N-(tert-butoxycarbonyl)-4-aminobutanoic acid

: 1248570-62-8
3-(4-formyl-2-hydroxyphenoxy)propyl nitrate

: 1447759-80-9
[5-formyl-2-(3-nitrooxypropoxy)phenyl]-4-(tert-butoxycarbonylamino)butanoate

Guidance literature:: N-(tert-butoxycarbonyl)-4-aminobutanoic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

3-(4-formyl-2-hydroxyphenoxy)propyl nitrate; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/cmdc.201300105

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1447759-80-9
[5-formyl-2-(3-nitrooxypropoxy)phenyl]-4-(tert-butoxycarbonylamino)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydrogencarbonate / acetonitrile / 4 h / 70 °C

2.1: silver nitrate / acetonitrile / 14 h / 70 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

With dmap; potassium hydrogencarbonate; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;
DOI:10.1002/cmdc.201300105

Reference yield:

: 1248570-61-7
4-(3-bromopropoxy)-3-hydroxybenzaldehyde

: 1447759-80-9
[5-formyl-2-(3-nitrooxypropoxy)phenyl]-4-(tert-butoxycarbonylamino)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: silver nitrate / acetonitrile / 14 h / 70 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With dmap; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;
DOI:10.1002/cmdc.201300105