Technology Process of Cbz-Phe-Pheψ-Glycinol
There total 7 articles about Cbz-Phe-Pheψ-Glycinol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 97 percent / 1.0 M DIBALH / toluene; hexane / 0.5 h
2: oxalylchloride / dimethylsulfoxide
3: tetrahydrofuran / -20 °C
5: TFA, Dowex OH- / CH2Cl2
6: 1.) N-methyl-morpholine, 2.) isobutylchloroformate / 1.) THF, 2.) DMF, r.t.
With
4-methyl-morpholine; Chloro-oxo-acetic acid; diisobutylaluminium hydride; trifluoroacetic acid; isobutyl chloroformate;
In
tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1016/S0040-4020(01)88232-6
- Guidance literature:
-
Multi-step reaction with 5 steps
1: oxalylchloride / dimethylsulfoxide
2: tetrahydrofuran / -20 °C
4: TFA, Dowex OH- / CH2Cl2
5: 1.) N-methyl-morpholine, 2.) isobutylchloroformate / 1.) THF, 2.) DMF, r.t.
With
4-methyl-morpholine; Chloro-oxo-acetic acid; trifluoroacetic acid; isobutyl chloroformate;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(01)88232-6
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetrahydrofuran / -20 °C
3: TFA, Dowex OH- / CH2Cl2
4: 1.) N-methyl-morpholine, 2.) isobutylchloroformate / 1.) THF, 2.) DMF, r.t.
With
4-methyl-morpholine; trifluoroacetic acid; isobutyl chloroformate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)88232-6
