N-(2,3,5,6-tetrafluorophenyl)acetamide

Base Information

• Chemical Name: N-(2,3,5,6-tetrafluorophenyl)acetamide
• CAS No.: 1766-14-9
• Molecular Formula: C8H5 F4 N O
• Molecular Weight: 207.127
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID40466505
• Wikidata: Q82293079
• Mol file: 1766-14-9.mol

Synonyms:N-(2,3,5,6-tetrafluorophenyl)acetamide;1766-14-9;2',3',5',6'-tetrafluoroacetanilide;Acetamide, N-(2,3,5,6-tetrafluorophenyl)-;SCHEMBL445173;DTXSID40466505;MFCD00039213;AKOS015964287;SB77598;AC-18557;BS-51558;FT-0715656;E84514

Chemical Property of N-(2,3,5,6-tetrafluorophenyl)acetamide

Chemical Property:

• Boiling Point: 241.643oC at 760 mmHg
• Flash Point: 99.942oC
• PSA: 29.10000
• Density: 1.486g/cm3
• LogP: 2.27440
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 207.03072643
• Heavy Atom Count: 14
• Complexity: 211

Purity/Quality:

95+% ^*data from raw suppliers

2',3',5',6'-TETRAFLUOROACETANILIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C(=CC(=C1F)F)F)F

Technology Process of N-(2,3,5,6-tetrafluorophenyl)acetamide

There total 8 articles about N-(2,3,5,6-tetrafluorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,3,5,6-tetrafluoroaniline (700-17-4) + acetic anhydride (108-24-7) → N-(2,3,5,6-tetrafluorophenyl)acetamide (1766-14-9)

Guidance literature:

With pyridine; at 120 ℃; for 2h;

DOI:10.1021/jm0492094

Reference yield: 82.0%

→ N-(2,3,5,6-tetrafluorophenyl)acetamide (1766-14-9)

Guidance literature:

Reference yield: 38.0%

1-Acetylamino-2,3,4,5,6-pentafluorobenzen (653-22-5) → N-(2,4,5-trifluorophenyl)acetamide (366-50-7) + N-(2,3,5,6-tetrafluorophenyl)acetamide (1766-14-9) + N-(2,3,4,5-tetrafluorophenyl)acetamide (16582-88-0)

Guidance literature:

With ammonium hydroxide; zinc(II) chloride; zinc; at 20 ℃; for 25h; Further Variations:; Reagents; Time; Product distribution;

DOI:10.1016/S0022-1139(01)00404-3

upstream raw materials:

2,3,5,6-tetrafluoroaniline

acetic anhydride

1-Acetylamino-2,3,4,5,6-pentafluorobenzen

Downstream raw materials:

2',3',5',6'-tetrafluorothioacetanilide

2,3,5-trifluoro aniline

2,3,5-trifluoroacetanilide

1,2,4,5-tetrafluoro-3,6-dinitrobenzene