4-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide

Base Information

Chemical Name:4-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide
CAS No.:212578-67-1
Molecular Formula:C₂₉H₃₄N₂O₄
Molecular Weight:474.6
Hs Code.:

Synonyms:4-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide

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Chemical Property of 4-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide

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Technology Process of 4-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide

There total 9 articles about 4-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 212578-66-0
4-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-butyric acid

: 212578-67-1
4-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm970795t

Reference yield:

: 1624-53-9,3230-45-3,137838-23-4
2-(benzylideneamino)phenol

: 212578-67-1
4-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide

Guidance literature:: Multi-step reaction with 9 steps

1: NaBH₄ / ethanol

2: NaHCO₃ / ethanol / 8 h / Ambient temperature

3: K₂CO₃ / ethanol / 1 h / Ambient temperature

4: 80 percent / LiAlH₄ / tetrahydrofuran

5: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂

6: 88 percent / toluene / 2 h / Heating

7: 65 percent / H₂ / Raney Ni / ethanol; H₂O / 4 h / 20 °C / 2585.7 Torr

8: 90 percent / KOH / ethanol / Heating

9: 79 percent / EDCI / CH₂Cl₂ / 2 h / Ambient temperature

With potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; nickel; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/jm970795t

Reference yield:

: 106201-20-1
4-benzyl-3,4-dihydro-2-(2-hydroxyethyl)-2H-1,4-benzoxazine

: 212578-67-1
4-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]butanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂

2: 88 percent / toluene / 2 h / Heating

3: 65 percent / H₂ / Raney Ni / ethanol; H₂O / 4 h / 20 °C / 2585.7 Torr

4: 90 percent / KOH / ethanol / Heating

5: 79 percent / EDCI / CH₂Cl₂ / 2 h / Ambient temperature

With potassium hydroxide; oxalyl dichloride; hydrogen; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; nickel; In ethanol; dichloromethane; water; toluene;
DOI:10.1021/jm970795t