3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

Base Information

Chemical Name:3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one
CAS No.:1574538-26-3
Molecular Formula:C₃₀H₃₄N₂O₃
Molecular Weight:470.612
Hs Code.:

Synonyms:3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

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Chemical Property of 3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

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Technology Process of 3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

There total 8 articles about 3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1574538-24-1
(±)-3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

: 1574538-25-2
3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

: 1574538-26-3
3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

Guidance literature:: With CHIRALCEL OD-H column; In ethanol; hexane; Resolution of racemate;

Reference yield:

: 178698-88-9
4-amino-2-ethylphenol

: 1574538-25-2
3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

: 1574538-26-3
3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / methanol / 10 h / 20 °C

2.1: potassium carbonate / acetonitrile / 16 h / 50 °C

3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

4.1: triethylamine / chloroform / 20 °C

4.2: AMBERLITE? IRA-400 / 12 h / Reflux

5.1: potassium iodide; caesium carbonate / acetonitrile / 12 h / Reflux

6.1: CHIRALCEL? OD-H column / ethanol; hexane / Resolution of racemate

With potassium carbonate; caesium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; In methanol; ethanol; hexane; dichloromethane; chloroform; acetonitrile;

Reference yield:

: 1574541-70-0
3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)aniline

: 1574538-25-2
3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

: 1574538-26-3
3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / chloroform / 20 °C

1.2: AMBERLITE? IRA-400 / 12 h / Reflux

2.1: potassium iodide; caesium carbonate / acetonitrile / 12 h / Reflux

3.1: CHIRALCEL? OD-H column / ethanol; hexane / Resolution of racemate

With caesium carbonate; triethylamine; potassium iodide; In ethanol; hexane; chloroform; acetonitrile;