O-[3-(4-methoxy-phenoxy)-6-phenyl-3,6-dihydro-2H-pyran-2-ylmethyl]-hydroxylamine

Base Information

Chemical Name:O-[3-(4-methoxy-phenoxy)-6-phenyl-3,6-dihydro-2H-pyran-2-ylmethyl]-hydroxylamine
CAS No.:859215-04-6
Molecular Formula:C₁₉H₂₁NO₄
Molecular Weight:327.38
Hs Code.:

<i>O</i>-[3-(4-methoxy-phenoxy)-6-phenyl-3,6-dihydro-2<i>H</i>-pyran-2-ylmethyl]-hydroxylamine

Synonyms:O-[3-(4-methoxy-phenoxy)-6-phenyl-3,6-dihydro-2H-pyran-2-ylmethyl]-hydroxylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of O-[3-(4-methoxy-phenoxy)-6-phenyl-3,6-dihydro-2H-pyran-2-ylmethyl]-hydroxylamine

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Technology Process of O-[3-(4-methoxy-phenoxy)-6-phenyl-3,6-dihydro-2H-pyran-2-ylmethyl]-hydroxylamine

There total 7 articles about O-[3-(4-methoxy-phenoxy)-6-phenyl-3,6-dihydro-2H-pyran-2-ylmethyl]-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 859215-13-7
2-(((2R,3S,6S)-3-(4-methoxyphenoxy)-3,6-dihydro-6-phenyl-2H-pyran-2-yl)methoxy)isoindoline-1,3-dione

: 859215-04-6
O-[3-(4-methoxy-phenoxy)-6-phenyl-3,6-dihydro-2H-pyran-2-ylmethyl]-hydroxylamine

Guidance literature:: With PS-diethylenetriamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol051023r

Reference yield:

: 859214-76-9
carbonic acid 2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl ester ethyl ester

: 859215-04-6
O-[3-(4-methoxy-phenoxy)-6-phenyl-3,6-dihydro-2H-pyran-2-ylmethyl]-hydroxylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform adduct; (1S,2S)-(-)-1,2-bis(2-diphenylphosphinobenzamido)cyclohexane / CH₂Cl₂ / 0.17 h / 100 °C / microwave irradiation

2: 80 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.08 h

3: pyridine / CH₂Cl₂ / 1 h / 0 °C

4: 215 mg / 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 0 - 20 °C

5: 95 percent / PS-diethylenetriamine / CH₂Cl₂ / 12 h / 20 °C

With pyridine; PS-diethylenetriamine; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ol051023r

Reference yield:

: 859214-75-8
carbonic acid 2-(tert-butyldimethyl-silanyloxymethyl)-4-ethoxycarbonyloxy-3,4-dihydro-2H-pyran-3-yl ester ethyl ester

: 859215-04-6
O-[3-(4-methoxy-phenoxy)-6-phenyl-3,6-dihydro-2H-pyran-2-ylmethyl]-hydroxylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / palladium(II) acetate / acetonitrile

2: 95 percent / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform adduct; (1S,2S)-(-)-1,2-bis(2-diphenylphosphinobenzamido)cyclohexane / CH₂Cl₂ / 0.17 h / 100 °C / microwave irradiation

3: 80 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.08 h

4: pyridine / CH₂Cl₂ / 1 h / 0 °C

5: 215 mg / 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 0 - 20 °C

6: 95 percent / PS-diethylenetriamine / CH₂Cl₂ / 12 h / 20 °C

With pyridine; PS-diethylenetriamine; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; palladium diacetate; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ol051023r