1-[(benzyloxy)methyl]-6-(3,5-dimethylbenzyl)-5-iodopyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-[(benzyloxy)methyl]-6-(3,5-dimethylbenzyl)-5-iodopyrimidine-2,4(1H,3H)-dione
CAS No.:1353715-19-1
Molecular Formula:C₂₁H₂₁IN₂O₃
Molecular Weight:476.314
Hs Code.:

Synonyms:1-[(benzyloxy)methyl]-6-(3,5-dimethylbenzyl)-5-iodopyrimidine-2,4(1H,3H)-dione

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Chemical Property of 1-[(benzyloxy)methyl]-6-(3,5-dimethylbenzyl)-5-iodopyrimidine-2,4(1H,3H)-dione

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Technology Process of 1-[(benzyloxy)methyl]-6-(3,5-dimethylbenzyl)-5-iodopyrimidine-2,4(1H,3H)-dione

There total 4 articles about 1-[(benzyloxy)methyl]-6-(3,5-dimethylbenzyl)-5-iodopyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 3587-60-8
Benzyloxymethyl chloride

: 1353715-17-9
C₁₃H₁₃IN₂O₂

: 1353715-19-1
1-[(benzyloxy)methyl]-6-(3,5-dimethylbenzyl)-5-iodopyrimidine-2,4(1H,3H)-dione

Guidance literature:: C₁₃H₁₃IN₂O₂; With N,O-bis-(trimethylsilyl)-acetamide; In chloroform; for 0.5h;

Benzyloxymethyl chloride; With lithium iodide; In chloroform; at 20 ℃; for 4h;
DOI:10.1021/jm201506e

Reference yield:

: 1204750-05-9
6-(3,5-dimethylbenzyl)pyrimidine-2,4(1H,3H)-dione

: 1353715-19-1
1-[(benzyloxy)methyl]-6-(3,5-dimethylbenzyl)-5-iodopyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: iodine; lead dioxide; acetic acid / 12 h / 50 °C

2.1: N,O-bis-(trimethylsilyl)-acetamide / chloroform / 0.5 h

2.2: 4 h / 20 °C

With N,O-bis-(trimethylsilyl)-acetamide; iodine; lead dioxide; acetic acid; In chloroform;
DOI:10.1021/jm201506e

Reference yield:

: 1353715-16-8
6-(3,5-dimethyl)benzyl-2-thiouracil

: 1353715-19-1
1-[(benzyloxy)methyl]-6-(3,5-dimethylbenzyl)-5-iodopyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloroacetic acid / water / 24 h / Reflux

2.1: iodine; lead dioxide; acetic acid / 12 h / 50 °C

3.1: N,O-bis-(trimethylsilyl)-acetamide / chloroform / 0.5 h

3.2: 4 h / 20 °C

With N,O-bis-(trimethylsilyl)-acetamide; iodine; lead dioxide; acetic acid; chloroacetic acid; In chloroform; water;
DOI:10.1021/jm201506e