N-(2-fluorophenyl)-4-methylbenzamide

Base Information

Chemical Name:N-(2-fluorophenyl)-4-methylbenzamide
CAS No.:5215-29-2
Molecular Formula:C₁₄H₁₂FNO
Molecular Weight:229.254
Hs Code.:
DSSTox Substance ID:DTXSID001291652
Mol file:5215-29-2.mol

Synonyms:N-(2-fluorophenyl)-4-methylbenzamide;5215-29-2;F0849-2133;SCHEMBL24886328;DTXSID001291652;MFCD00995784;STK044880;AKOS001594948;EU-0002753;SR-01000411218;SR-01000411218-1;Z28290365

Suppliers and Price of N-(2-fluorophenyl)-4-methylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N-(2-fluorophenyl)-4-methylbenzamide

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:229.090292168
Heavy Atom Count:17
Complexity:261

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2F

Technology Process of N-(2-fluorophenyl)-4-methylbenzamide

There total 4 articles about N-(2-fluorophenyl)-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 348-54-9
2-Fluoroaniline

: 874-60-2
4-methyl-benzoyl chloride

: 5215-29-2
N-(2-fluorophenyl)-4-methylbenzamide

Guidance literature:: With pyridine; for 2h; Reflux;
DOI:10.1016/j.jmgm.2010.04.003

Reference yield:

: 348-54-9
2-Fluoroaniline

: C₂₂H₂₂N₂O₃

: 5215-29-2
N-(2-fluorophenyl)-4-methylbenzamide

Guidance literature:: With (3-phenylallyl)(chloro)-[1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene]palladium(II); potassium carbonate; In tetrahydrofuran; at 25 - 110 ℃; for 24h; Inert atmosphere;
DOI:10.3390/molecules24071234

Reference yield:

: 33757-49-2
4-methyl-N-(quinolin-8-yl)benzamide

: 5215-29-2
N-(2-fluorophenyl)-4-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / acetonitrile / 15 h / 25 °C / Schlenk technique

2: potassium carbonate; (3-phenylallyl)(chloro)-[1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene]palladium(II) / tetrahydrofuran / 24 h / 25 - 110 °C / Inert atmosphere

With dmap; (3-phenylallyl)(chloro)-[1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene]palladium(II); potassium carbonate; In tetrahydrofuran; acetonitrile;
DOI:10.3390/molecules24071234