3-[(1R,3R,3aS,7aR)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-oxo-tetrahydro-2,4,6-trioxa-5λ⁵-phospha-inden-5-yloxy]-propionitrile

Base Information

• Chemical Name: 3-[(1R,3R,3aS,7aR)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-oxo-tetrahydro-2,4,6-trioxa-5λ⁵-phospha-inden-5-yloxy]-propionitrile
• CAS No.: 219571-04-7
• Molecular Formula: C₃₄H₃₄N₃O₁₀P
• Molecular Weight: 675.632

Synonyms:3-[(1R,3R,3aS,7aR)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-oxo-tetrahydro-2,4,6-trioxa-5λ⁵-phospha-inden-5-yloxy]-propionitrile

Chemical Property of 3-[(1R,3R,3aS,7aR)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-oxo-tetrahydro-2,4,6-trioxa-5λ⁵-phospha-inden-5-yloxy]-propionitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(1R,3R,3aS,7aR)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-oxo-tetrahydro-2,4,6-trioxa-5λ⁵-phospha-inden-5-yloxy]-propionitrile

There total 7 articles about 3-[(1R,3R,3aS,7aR)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-oxo-tetrahydro-2,4,6-trioxa-5λ⁵-phospha-inden-5-yloxy]-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-[(1R,3R,3aS,7aR)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-2,4,6-trioxa-5-phospha-inden-5-yloxy]-propionitrile → 3-[(1R,3R,3aS,7aR)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-oxo-tetrahydro-2,4,6-trioxa-5λ5-phospha-inden-5-yloxy]-propionitrile (219571-04-7)

Guidance literature:

With pyridine; iodine; In water;

DOI:10.1016/S0040-4039(98)01952-2

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 3-[(1R,3R,3aS,7aR)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-oxo-tetrahydro-2,4,6-trioxa-5λ5-phospha-inden-5-yloxy]-propionitrile (219571-04-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / pyridine / CH₂Cl₂

2: NH₃ / methanol

3: tetrazole / acetonitrile

4: 67 percent / I₂, pyridine / H₂O

With pyridine; 1H-tetrazole; ammonia; iodine; In methanol; dichloromethane; water; acetonitrile;

DOI:10.1016/S0040-4039(98)01952-2

Reference yield:

2'-deoxy-2'-α-C-(acetoxymethyl)uridine (692781-24-1) → 3-[(1R,3R,3aS,7aR)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-oxo-tetrahydro-2,4,6-trioxa-5λ5-phospha-inden-5-yloxy]-propionitrile (219571-04-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / pyridine / CH₂Cl₂

2: NH₃ / methanol

3: tetrazole / acetonitrile

4: 67 percent / I₂, pyridine / H₂O

With pyridine; 1H-tetrazole; ammonia; iodine; In methanol; dichloromethane; water; acetonitrile;

DOI:10.1016/S0040-4039(98)01952-2

upstream raw materials:

4,4'-dimethoxytrityl chloride

2'-deoxy-2'-α-C-(acetoxymethyl)uridine

1-((2R,3R,3aS,9aR)-3-Hydroxymethyl-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

Acetic acid (2R,3R,3aS,9aR)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 219571-04-7 3-[(1R,3R,3aS,7aR)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-oxo-tetrahydro-2,4,6-trioxa-5λ⁵-phospha-inden-5-yloxy]-propionitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send