trans-(2R^*,3S^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylic acid

Base Information

• Chemical Name: trans-(2R^*,3S^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylic acid
• CAS No.: 128080-53-5
• Molecular Formula: C₁₇H₁₄O₃
• Molecular Weight: 266.296

Synonyms:trans-(2R^*,3S^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylic acid

Chemical Property of trans-(2R^*,3S^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylic acid

Chemical Property:

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Technology Process of trans-(2R^*,3S^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylic acid

There total 3 articles about trans-(2R^*,3S^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

diethyl 2-phenyl-1,2,3,4-tetrahydronapthalene-1-one-3,3-dicarboxylate (104958-17-0) → trans-(2R*,3S*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylic acid (128080-53-5)

Guidance literature:

With potassium hydroxide; water; In 1,4-dioxane; ethylene glycol; for 3h; Heating;

Reference yield:

diethyl 2-phenyl-1,2,3,4-tetrahydronapthalene-1-one-3,3-dicarboxylate (104958-17-0) → 4-oxo-3-phenyl-1,2,3,4-tetrahydro-[2]naphthoic acid (128080-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol. NaOH-solution

2: 150 °C

With sodium hydroxide;

DOI:10.1007/BF03166116

Reference yield:

4-oxo-3-phenyl-3,4-dihydro-1H-naphthalene-2,2-dicarboxylic acid (721918-02-1) → 4-oxo-3-phenyl-1,2,3,4-tetrahydro-[2]naphthoic acid (128080-53-5)

Guidance literature:

at 150 ℃;

DOI:10.1007/BF03166116

upstream raw materials:

4-oxo-3-phenyl-3,4-dihydro-1H-naphthalene-2,2-dicarboxylic acid

diethyl 2-phenyl-1,2,3,4-tetrahydronapthalene-1-one-3,3-dicarboxylate

Downstream raw materials:

methyl trans-(2R^*,3R^*)-3-phenyl-1,2,3,4-tetrahydronaphthalen-4-one-2-carboxylate

methyl 3,3,4,4,5,5-hexahydro-3-phenylbenzoazepin-1-one-4-carboxylate

(E)-methyl 3-phenyl-4-hydroxyimino-1,2,3,4-tetrahydronaphthalene-2-carboxylate

(Z)-methyl 3-phenyl-4-hydroxyimino-1,2,3,4-tetrahydronaphthalene-2-carboxylate

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