di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-carboxypropylamino)>glutamyl-glutamate

Base Information

Chemical Name:di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-carboxypropylamino)>glutamyl-glutamate
CAS No.:120092-33-3
Molecular Formula:C₄₁H₅₃N₇O₁₀
Molecular Weight:803.913
Hs Code.:

di(t-butyl) p-<N-<(2-amino-4-hydroxy-6-quinazolinyl)methyl>-N-2-propynylamino>benzoyl-γ-<α-(3-carboxypropylamino)>glutamyl-glutamate

Synonyms:di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-carboxypropylamino)>glutamyl-glutamate

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Chemical Property of di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-carboxypropylamino)>glutamyl-glutamate

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Technology Process of di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-carboxypropylamino)>glutamyl-glutamate

There total 9 articles about di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-carboxypropylamino)>glutamyl-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 120092-32-2
di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-methoxycarbonylpropylamino)>glutamyl-glutamate

: 120092-33-3
di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-carboxypropylamino)>glutamyl-glutamate

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 25 ℃; for 0.75h;

Reference yield:

: 3886-08-6
5-tert-butyl N-benzyloxycarbonyl-L-glutamate

: 120092-33-3
di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-carboxypropylamino)>glutamyl-glutamate

Guidance literature:: Multi-step reaction with 9 steps

1: 1. N-methylmorpholine, isobutyl chlorocarbonate; 2. N-methylmorpholine / 1. THF, -20 deg C, 4 min; 2. 45 min, -10 to 10 deg C

2: 90 percent / H₂ / Pd/C / methanol / 2.5 h / 21 °C

3: 66 percent / tributylamine / dioxane / 0.33 h

4: 78 percent / CF₃COOH / 0.25 h

5: 1. N-methylmorpholine, isobutyl chlorocarbonate; 2. N-methylmorpholine / 1. DMF, -15 deg C, 4 min; 2. 45 min, -10 to 10 deg C

6: H₂ / Pd/C / methanol / 0.33 h / 21 °C

7: CaCO₃ / N,N-dimethyl-acetamide / 165 h / 21 - 22 °C

8: 55 percent / CaCO₃ / N,N-dimethyl-acetamide / 168 h / 25 - 27 °C

9: 84 percent / NaOH / H₂O; dioxane / 0.75 h / 25 °C

With 4-methyl-morpholine; sodium hydroxide; tributyl-amine; hydrogen; trifluoroacetic acid; calcium carbonate; isobutyl chloroformate; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl acetamide; water;

Reference yield:

: 120092-04-8
(S)-4-Amino-4-(3-methoxycarbonyl-propylcarbamoyl)-butyric acid tert-butyl ester

: 120092-33-3
di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-carboxypropylamino)>glutamyl-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1: 66 percent / tributylamine / dioxane / 0.33 h

2: 78 percent / CF₃COOH / 0.25 h

3: 1. N-methylmorpholine, isobutyl chlorocarbonate; 2. N-methylmorpholine / 1. DMF, -15 deg C, 4 min; 2. 45 min, -10 to 10 deg C

4: H₂ / Pd/C / methanol / 0.33 h / 21 °C

5: CaCO₃ / N,N-dimethyl-acetamide / 165 h / 21 - 22 °C

6: 55 percent / CaCO₃ / N,N-dimethyl-acetamide / 168 h / 25 - 27 °C

7: 84 percent / NaOH / H₂O; dioxane / 0.75 h / 25 °C

With 4-methyl-morpholine; sodium hydroxide; tributyl-amine; hydrogen; trifluoroacetic acid; calcium carbonate; isobutyl chloroformate; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl acetamide; water;