(R)-[3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl]{2-[2,2,2-trifluoro-1-(methoxymethoxy)-1-(trifluoromethyl)ethyl]-1,3-thiazol-5-yl}methanol

Base Information

• Chemical Name: (R)-[3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl]{2-[2,2,2-trifluoro-1-(methoxymethoxy)-1-(trifluoromethyl)ethyl]-1,3-thiazol-5-yl}methanol
• CAS No.: 648929-25-3
• Molecular Formula: C₁₉H₁₇F₈NO₅S
• Molecular Weight: 523.401
• Mol file: 648929-25-3.mol

Synonyms:(R)-[3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl]{2-[2,2,2-trifluoro-1-(methoxymethoxy)-1-(trifluoromethyl)ethyl]-1,3-thiazol-5-yl}methanol

Chemical Property of (R)-[3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl]{2-[2,2,2-trifluoro-1-(methoxymethoxy)-1-(trifluoromethyl)ethyl]-1,3-thiazol-5-yl}methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-[3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl]{2-[2,2,2-trifluoro-1-(methoxymethoxy)-1-(trifluoromethyl)ethyl]-1,3-thiazol-5-yl}methanol

There total 1 articles about (R)-[3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl]{2-[2,2,2-trifluoro-1-(methoxymethoxy)-1-(trifluoromethyl)ethyl]-1,3-thiazol-5-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl]{2-[2,2,2-trifluoro-1-(methoxymethoxy)-1-(trifluoromethyl)ethyl]-1,3-thiazol-5-yl}methanone (648929-16-2) → (R)-[3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl]{2-[2,2,2-trifluoro-1-(methoxymethoxy)-1-(trifluoromethyl)ethyl]-1,3-thiazol-5-yl}methanol (648929-25-3)

Guidance literature:

With (BINAP-based ligand)[(NH₂CH₂)2-based chiral ligand]RuCl₂; hydrogen; potassium carbonate; In tetrahydrofuran; isopropyl alcohol; at 25 ℃; under 2068.59 Torr;

DOI:10.1021/ol0360795

Reference yield:

(S)-2-methoxy-2-phenylacetic acid (26164-26-1) + (R)-[3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl]{2-[2,2,2-trifluoro-1-(methoxymethoxy)-1-(trifluoromethyl)ethyl]-1,3-thiazol-5-yl}methanol (648929-25-3) → (S)-Methoxy-phenyl-acetic acid (R)-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-[2-(2,2,2-trifluoro-1-methoxymethoxy-1-trifluoromethyl-ethyl)-thiazol-5-yl]-methyl ester

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

DOI:10.1016/j.tetlet.2005.06.009

Reference yield:

(R)-methoxyphenylacetic acid (3966-32-3) + (R)-[3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl]{2-[2,2,2-trifluoro-1-(methoxymethoxy)-1-(trifluoromethyl)ethyl]-1,3-thiazol-5-yl}methanol (648929-25-3) → (R)-Methoxy-phenyl-acetic acid (R)-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-[2-(2,2,2-trifluoro-1-methoxymethoxy-1-trifluoromethyl-ethyl)-thiazol-5-yl]-methyl ester

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

DOI:10.1016/j.tetlet.2005.06.009

upstream raw materials:

[3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl]{2-[2,2,2-trifluoro-1-(methoxymethoxy)-1-(trifluoromethyl)ethyl]-1,3-thiazol-5-yl}methanone