N-(3,5-difluoro-4-hydroxyphenyl)-N'-[3-(trifluoromethyl)phenyl]urea

Base Information

• Chemical Name: N-(3,5-difluoro-4-hydroxyphenyl)-N'-[3-(trifluoromethyl)phenyl]urea
• CAS No.: 1268490-54-5
• Molecular Formula: C₁₄H₉F₅N₂O₂
• Molecular Weight: 332.23
• Mol file: 1268490-54-5.mol

Synonyms:N-(3,5-difluoro-4-hydroxyphenyl)-N'-[3-(trifluoromethyl)phenyl]urea

Chemical Property of N-(3,5-difluoro-4-hydroxyphenyl)-N'-[3-(trifluoromethyl)phenyl]urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,5-difluoro-4-hydroxyphenyl)-N'-[3-(trifluoromethyl)phenyl]urea

There total 2 articles about N-(3,5-difluoro-4-hydroxyphenyl)-N'-[3-(trifluoromethyl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

2,6-di-fluoro-4-aminophenol (126058-97-7) + 1-isocyanato-3-trifluoromethyl-benzene (329-01-1) → N-(3,5-difluoro-4-hydroxyphenyl)-N'-[3-(trifluoromethyl)phenyl]urea (1268490-54-5)

Guidance literature:

In pyridine; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

2,6-Difluoro-4-nitrophenol (658-07-1) → N-(3,5-difluoro-4-hydroxyphenyl)-N'-[3-(trifluoromethyl)phenyl]urea (1268490-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; ammonium chloride / ethanol; water / 16 h / 80 °C

2: pyridine / N,N-dimethyl-formamide / 20 °C

With pyridine; iron; ammonium chloride; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.1c00700

Reference yield: 58.0%

4,6-dichloropyrimidine (1193-21-1) + N-(3,5-difluoro-4-hydroxyphenyl)-N'-[3-(trifluoromethyl)phenyl]urea (1268490-54-5) → N-{4-[(6-chloro-4-pyrimidinyl)oxy]-3,5-difluorophenyl}-N'-[3-(trifluoromethyl)phenyl]urea (1268490-55-6)

Guidance literature:

With potassium tert-butylate; potassium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

2,6-di-fluoro-4-aminophenol

1-isocyanato-3-trifluoromethyl-benzene

2,6-Difluoro-4-nitrophenol

Downstream raw materials:

N-{4-[(6-chloro-4-pyrimidinyl)oxy]-3,5-difluorophenyl}-N'-[3-(trifluoromethyl)phenyl]urea

1-(3,5-difluoro-4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea