4-(2-((4-chloro-5-(pyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methylamino)pyridin-4-yl)-3-methylbenzonitrile

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Chemical Name:4-(2-((4-chloro-5-(pyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methylamino)pyridin-4-yl)-3-methylbenzonitrile
CAS No.:1388021-42-8
Molecular Formula:C₂₇H₂₅ClN₆O
Molecular Weight:484.988
Hs Code.:

Synonyms:4-(2-((4-chloro-5-(pyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methylamino)pyridin-4-yl)-3-methylbenzonitrile

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Chemical Property of 4-(2-((4-chloro-5-(pyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methylamino)pyridin-4-yl)-3-methylbenzonitrile

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Technology Process of 4-(2-((4-chloro-5-(pyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methylamino)pyridin-4-yl)-3-methylbenzonitrile

There total 9 articles about 4-(2-((4-chloro-5-(pyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methylamino)pyridin-4-yl)-3-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1388021-41-7
4-chloro-5-(pyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carbaldehyde

: 1224740-91-3
4-(2-aminopyridin-4-yl)-3-methylbenzonitrile

: 1388021-42-8
4-(2-((4-chloro-5-(pyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methylamino)pyridin-4-yl)-3-methylbenzonitrile

Guidance literature:: 4-chloro-5-(pyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carbaldehyde; 4-(2-aminopyridin-4-yl)-3-methylbenzonitrile; With acetic acid; In 1,2-dichloro-ethane; at 25 ℃; for 1h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 25 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ml300146q

Reference yield:

: 1388021-40-6
(4-chloro-5-(pyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methanol

: 1388021-42-8
4-(2-((4-chloro-5-(pyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methylamino)pyridin-4-yl)-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C / Inert atmosphere

2.1: acetic acid / 1,2-dichloro-ethane / 1 h / 25 °C / Inert atmosphere

2.2: 16 h / 25 °C / Inert atmosphere

With Dess-Martin periodane; acetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ml300146q

Reference yield:

: 313546-18-8
(4-cyano-2-methylphenyl)boronic acid

: 1388021-42-8
4-(2-((4-chloro-5-(pyridin-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methylamino)pyridin-4-yl)-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; water / 2 h / 140 °C / Inert atmosphere

2.1: acetic acid / 1,2-dichloro-ethane / 1 h / 25 °C / Inert atmosphere

2.2: 16 h / 25 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; acetic acid; In 1,2-dimethoxyethane; water; 1,2-dichloro-ethane; 1.1: |Suzuki Coupling;
DOI:10.1021/ml300146q