(4R,6S)-2-Benzyloxymethyl-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methyl-tetrahydro-pyran-2-ol

Base Information

Chemical Name:(4R,6S)-2-Benzyloxymethyl-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methyl-tetrahydro-pyran-2-ol
CAS No.:880344-71-8
Molecular Formula:C₃₈H₅₆O₅Si₂
Molecular Weight:649.031
Hs Code.:

Synonyms:(4R,6S)-2-Benzyloxymethyl-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methyl-tetrahydro-pyran-2-ol

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Chemical Property of (4R,6S)-2-Benzyloxymethyl-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methyl-tetrahydro-pyran-2-ol

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Technology Process of (4R,6S)-2-Benzyloxymethyl-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methyl-tetrahydro-pyran-2-ol

There total 7 articles about (4R,6S)-2-Benzyloxymethyl-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methyl-tetrahydro-pyran-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 880344-69-4
(4R,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methyl-tetrahydro-pyran-2-one

: 66222-28-4
(benzyloxymethyl)tributylstannane

: 880344-71-8
(4R,6S)-2-Benzyloxymethyl-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methyl-tetrahydro-pyran-2-ol

Guidance literature:: (benzyloxymethyl)tributylstannane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

(4R,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methyl-tetrahydro-pyran-2-one; In tetrahydrofuran; hexane; at -78 - -40 ℃; for 1h;
DOI:10.1021/ja0547477

Reference yield:

: 880344-67-2
(S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-5,6-dihydro-pyran-2-one

: 880344-71-8
(4R,6S)-2-Benzyloxymethyl-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methyl-tetrahydro-pyran-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuCN / diethyl ether / 1 h / -78 - 0 °C

1.2: diethyl ether / 0.33 h / -78 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

2.2: tetrahydrofuran; hexane / 1 h / -78 - -40 °C

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/ja0547477

Reference yield:

: 79364-35-5
(S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)but-3-en-1-ol

: 880344-71-8
(4R,6S)-2-Benzyloxymethyl-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methyl-tetrahydro-pyran-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 73 percent / DCC; 4-DMAP / CH₂Cl₂ / 18 h / 25 °C

2.1: 95 percent / Grubbs first generation catalyst / CH₂Cl₂ / 5 h / 40 °C

3.1: aq. AcOH / 2 h / 55 °C

4.1: 2.95 g / 4-DMAP; Et₃N / CH₂Cl₂ / 4 h / 0 - 25 °C

5.1: 88 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

6.1: CuCN / diethyl ether / 1 h / -78 - 0 °C

6.2: diethyl ether / 0.33 h / -78 °C

7.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

7.2: tetrahydrofuran; hexane / 1 h / -78 - -40 °C

With 2,6-dimethylpyridine; dmap; Grubbs catalyst first generation; n-butyllithium; acetic acid; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/ja0547477