1-(2,4-Dichlorophenyl)-N-1-piperidinyl-4-[[(1-pyrrolidinylsulfonyl)amino]methyl]-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:1-(2,4-Dichlorophenyl)-N-1-piperidinyl-4-[[(1-pyrrolidinylsulfonyl)amino]methyl]-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-1H-pyrazole-3-carboxamide
CAS No.:1429239-98-4
Molecular Formula:C₃₃H₃₁Cl₂F₃N₆O₃S₂
Molecular Weight:751.681
Hs Code.:
Mol file:1429239-98-4.mol

1-(2,4-Dichlorophenyl)-N-1-piperidinyl-4-[[(1-pyrrolidinylsulfonyl)amino]methyl]-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-1H-pyrazole-3-carboxamide

Synonyms:1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide

Suppliers and Price of 1-(2,4-Dichlorophenyl)-N-1-piperidinyl-4-[[(1-pyrrolidinylsulfonyl)amino]methyl]-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-1H-pyrazole-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
CB1-IN-1(BPRCB1184) >98%
1 g
$ 3500.00

DC Chemicals
CB1-IN-1(BPRCB1184) >98%
250 mg
$ 1750.00

Crysdot
CB1-IN-1 98+%
100mg
$ 1459.00

Crysdot
CB1-IN-1 98+%
10mg
$ 347.00

Crysdot
CB1-IN-1 98+%
5mg
$ 243.00

Crysdot
CB1-IN-1 98+%
50mg
$ 1042.00

ChemScene
CB1-IN-1 99.77%
10mg
$ 600.00

ChemScene
CB1-IN-1 99.77%
5mg
$ 420.00

ChemScene
CB1-IN-1 99.77%
100mg
$ 2520.00

ChemScene
CB1-IN-1 99.77%
50mg
$ 1800.00

Total 13 raw suppliers

Chemical Property of 1-(2,4-Dichlorophenyl)-N-1-piperidinyl-4-[[(1-pyrrolidinylsulfonyl)amino]methyl]-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-1H-pyrazole-3-carboxamide

Chemical Property:

PKA:10.21±0.20(Predicted)
Density:1.49±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

CB1-IN-1(BPRCB1184) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(2,4-Dichlorophenyl)-N-1-piperidinyl-4-[[(1-pyrrolidinylsulfonyl)amino]methyl]-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-1H-pyrazole-3-carboxamide

There total 11 articles about 1-(2,4-Dichlorophenyl)-N-1-piperidinyl-4-[[(1-pyrrolidinylsulfonyl)amino]methyl]-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1689-02-7
N-pyrrolidinesulfonyl chloride

: 1429242-17-0
4-(aminomethyl)-1-(2,4-dichlorophenyl)-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

: 1429239-98-4
1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

Reference yield:

: 1013649-25-6
5-(5-bromothiophen-2-yl)-1-(2,4-dichloro-phenyl)-4-methyl-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1429239-98-4
1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Reflux

2.1: silver nitrate; water / acetone / 60 °C

3.1: aluminum (III) chloride / 1,2-dichloro-ethane / 16 h / 0 - 20 °C / Inert atmosphere

4.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; water / 0.17 h / Inert atmosphere

4.2: 12 h / 80 °C / Inert atmosphere

5.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

6.1: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

7.1: triphenylphosphine / tetrahydrofuran; water / 16 h / 20 °C

8.1: triethylamine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; sodium azide; 2,2'-azobis(isobutyronitrile); water; phosphorus tribromide; silver nitrate; triethylamine; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1160842-73-8
ethyl 4-(bromomethyl)-5-(5-bromothiophene-2-yl)-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate

: 1429239-98-4
1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: silver nitrate; water / acetone / 60 °C

2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 16 h / 0 - 20 °C / Inert atmosphere

3.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; water / 0.17 h / Inert atmosphere

3.2: 12 h / 80 °C / Inert atmosphere

4.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

6.1: triphenylphosphine / tetrahydrofuran; water / 16 h / 20 °C

7.1: triethylamine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; water; phosphorus tribromide; silver nitrate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;