tert-butyl ((5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)carbamate

Base Information

Chemical Name:tert-butyl ((5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)carbamate
CAS No.:1268997-71-2
Molecular Formula:C₂₇H₂₉ClN₄O₆S
Molecular Weight:573.069
Hs Code.:

Synonyms:tert-butyl ((5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)carbamate

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Chemical Property of tert-butyl ((5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)carbamate

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Technology Process of tert-butyl ((5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)carbamate

There total 1 articles about tert-butyl ((5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1335316-92-1
tert-butyl ((5-(4-(4-(benzyloxy)-3-chlorophenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)carbamate

: 1268997-71-2
tert-butyl ((5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)carbamate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 48h;
DOI:10.1002/jlcr.1898

Reference yield:

: 1335316-95-4
[¹⁸F]-3-fluorobenzyl bromide

: 1268997-71-2
tert-butyl ((5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)carbamate

: C₃₄H₃₄Cl⁽¹⁸⁾FN₄O₆S

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1002/jlcr.1898

Reference yield:

: 1335316-95-4
[¹⁸F]-3-fluorobenzyl bromide

: 1268997-71-2
tert-butyl ((5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)carbamate

: 1335316-97-6
[18F]lapatinib

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 110 °C / Microwave irradiation

2: trifluoroacetic acid / N,N-dimethyl-formamide / 0.17 h / 100 °C / Microwave irradiation

With potassium carbonate; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1002/jlcr.1898