2-(5-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-pent-2-ynyloxy)-tetrahydro-pyran

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Chemical Name:2-(5-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-pent-2-ynyloxy)-tetrahydro-pyran
CAS No.:220173-67-1
Molecular Formula:C₄₆H₈₀O₅Si₂
Molecular Weight:769.309
Hs Code.:

2-(5-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-pent-2-ynyloxy)-tetrahydro-pyran

Synonyms:2-(5-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-pent-2-ynyloxy)-tetrahydro-pyran

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Chemical Property of 2-(5-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-pent-2-ynyloxy)-tetrahydro-pyran

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Technology Process of 2-(5-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-pent-2-ynyloxy)-tetrahydro-pyran

There total 13 articles about 2-(5-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-pent-2-ynyloxy)-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 81522-68-1
[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

: 220173-66-0
(1R,3aR,7aS)-1-Isopropyl-7a-[5-methyl-5-(tetrahydro-pyran-2-yloxy)-hex-3-ynyloxymethyl]-octahydro-inden-4-one

: 220173-67-1
2-(5-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-pent-2-ynyloxy)-tetrahydro-pyran

Guidance literature:: DOI:10.1016/S0968-0896(98)00161-8

Reference yield:

: 132101-64-5,27943-46-0
3-methyl-3-(tetrahydro-2H-pyran-2-yloxy)butyne

: 220173-67-1
2-(5-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-pent-2-ynyloxy)-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / n-butyl lithium / dioxane; hexane / 48 h / 90 °C

2: 62 percent / tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 3 h / 60 °C

3: 60 percent / pyridinium dichromate / CH₂Cl₂ / 18 h / Ambient temperature

4: 40 percent

With dipyridinium dichromate; n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;
DOI:10.1016/S0968-0896(98)00161-8

Reference yield:

: 66774-80-9,111924-49-3
(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate

: 220173-67-1
2-(5-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-pent-2-ynyloxy)-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 13 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 21 h / Heating

2: 88 percent / lead tetraacetate, pyridine / benzene / 3.5 h / 15 °C / Irradiation

3: 39 percent / boron trifluoride etherate / -20 deg C, 45 min, room temperature, 1 h

4: 65 percent / potassium hydroxide / methanol / 2.5 h / Heating

5: 94 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

6: 87 percent / potassium hydride, 18-crown-6 / tetrahydrofuran / -78 - 20 °C

7: 1.) ozone, 2.) triphenylphosphine / 1.) dichloromethane, methanol, -70 deg C, 30 min, 2.) -70 deg C, 30 min

8: 76 percent / sodium borohydride / tetrahydrofuran; methanol / 0.58 h

9: 59 percent / pyridine / 4 h / 0 °C

10: 55 percent / n-butyl lithium / dioxane; hexane / 48 h / 90 °C

11: 62 percent / tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 3 h / 60 °C

12: 60 percent / pyridinium dichromate / CH₂Cl₂ / 18 h / Ambient temperature

13: 40 percent

With pyridine; 1H-imidazole; lead(IV) acetate; potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; 18-crown-6 ether; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium hydride; ozone; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(98)00161-8