(R)-4-((7-(3,4-dimethoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

Base Information

Chemical Name:(R)-4-((7-(3,4-dimethoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one
CAS No.:1319738-10-7
Molecular Formula:C₂₁H₂₁N₃O₄
Molecular Weight:379.415
Hs Code.:

Synonyms:(R)-4-((7-(3,4-dimethoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

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Chemical Property of (R)-4-((7-(3,4-dimethoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

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Technology Process of (R)-4-((7-(3,4-dimethoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

There total 3 articles about (R)-4-((7-(3,4-dimethoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₉N₃O₄

: 1319738-10-7
(R)-4-((7-(3,4-dimethoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

Guidance literature:: With trifluoroacetic acid; at 160 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 99735-43-0,96449-93-3,99735-44-1
(3R)-1-((R)-1-phenylethyl)-5-oxo-3-pyrrolidinecarboxylic acid

: 1319738-10-7
(R)-4-((7-(3,4-dimethoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 2.5 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl acetamide / 0.25 h / 20 °C

2.2: 50 - 80 °C

3.1: trifluoroacetic acid / 0.5 h / 160 °C / Microwave irradiation

With dimethylsulfide borane complex; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 190957-22-3
(4R,1'R)-1-(1'-phenylethyl)-4-hydroxymethylpyrrolidin-2-one

: 1319738-10-7
(R)-4-((7-(3,4-dimethoxyphenyl)-1,6-naphthyridine-5-yloxy)methyl)pyrrolidine-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl acetamide / 0.25 h / 20 °C

1.2: 50 - 80 °C

2.1: trifluoroacetic acid / 0.5 h / 160 °C / Microwave irradiation

With sodium hydride; trifluoroacetic acid; In N,N-dimethyl acetamide;