N-benzyl-N-tert-butoxycarbonyl-5-(tert-butyldimethylsiloxy)-1-pentynylamine

Base Information

Chemical Name:N-benzyl-N-tert-butoxycarbonyl-5-(tert-butyldimethylsiloxy)-1-pentynylamine
CAS No.:609769-62-2
Molecular Formula:C₂₃H₃₇NO₃Si
Molecular Weight:403.637
Hs Code.:

Synonyms:N-benzyl-N-tert-butoxycarbonyl-5-(tert-butyldimethylsiloxy)-1-pentynylamine

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Chemical Property of N-benzyl-N-tert-butoxycarbonyl-5-(tert-butyldimethylsiloxy)-1-pentynylamine

Chemical Property:

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Technology Process of N-benzyl-N-tert-butoxycarbonyl-5-(tert-butyldimethylsiloxy)-1-pentynylamine

There total 4 articles about N-benzyl-N-tert-butoxycarbonyl-5-(tert-butyldimethylsiloxy)-1-pentynylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 42116-44-9
N-tert-butoxycarbonylbenzylamine

: 474022-55-4
[(5-bromo-4-pentyn-1-yl)oxy](tert-butyl)dimethyl-silane

: 609769-62-2
N-benzyl-N-tert-butoxycarbonyl-5-(tert-butyldimethylsiloxy)-1-pentynylamine

Guidance literature:: N-tert-butoxycarbonylbenzylamine; With pyridine; copper(l) iodide; potassium hexamethylsilazane; In tetrahydrofuran; at 20 ℃; for 2h;

[(5-bromo-4-pentyn-1-yl)oxy](tert-butyl)dimethyl-silane; In tetrahydrofuran; benzene; at 20 ℃; for 20h;
DOI:10.1021/ol035647d

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 609769-62-2
N-benzyl-N-tert-butoxycarbonyl-5-(tert-butyldimethylsiloxy)-1-pentynylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N / CH₂Cl₂ / 14 h / 20 °C

2.1: pyridine; KHMDS; CuI / tetrahydrofuran / 2 h / 20 °C

2.2: 53 percent / tetrahydrofuran; benzene / 20 h / 20 °C

With pyridine; copper(l) iodide; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol035647d

Reference yield:

: 61362-77-4
5-[tert-butyldimethylsilyloxy]pent-1-yne

: 609769-62-2
N-benzyl-N-tert-butoxycarbonyl-5-(tert-butyldimethylsiloxy)-1-pentynylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: AgNO₃; NBS / l

2.1: pyridine; KHMDS; CuI / tetrahydrofuran / 2 h / 20 °C

2.2: 53 percent / tetrahydrofuran; benzene / 20 h / 20 °C

With pyridine; N-Bromosuccinimide; copper(l) iodide; potassium hexamethylsilazane; silver nitrate; In tetrahydrofuran;
DOI:10.1021/ol035647d