(3S,4R)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

Base Information

Chemical Name:(3S,4R)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone
CAS No.:111865-89-5
Molecular Formula:C₃₀H₃₅NO₅
Molecular Weight:489.612
Hs Code.:

Synonyms:(3S,4R)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

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Chemical Property of (3S,4R)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

Chemical Property:

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Technology Process of (3S,4R)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

There total 1 articles about (3S,4R)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111865-66-8
(3S,4R)-1-(di-p-anisylmethyl)-3-acetyl-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

: 111955-99-8
(3S,4R)-1-(di-p-anisylmethyl)-3-<(S)-1-hydroxyethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

: 111865-89-5
(3S,4R)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

Guidance literature:: With potassium tri-sec-butyl-borohydride; potassium iodide; In tetrahydrofuran; at 0 ℃; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(00)85442-8

Reference yield: 91.0%

: 111865-89-5
(3S,4R)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

: 111865-81-7
(3S,4R)-3-<(R)-1-hydroxyethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile; at 0 ℃;
DOI:10.1016/S0040-4039(00)85442-8

Reference yield:

: 111865-89-5
(3S,4R)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-<(R)-1-(benzyloxymethyl)ethyl>-2-azetidinone

: 93711-85-4,97101-07-0,113033-46-8,120710-59-0,120710-60-3,90776-58-2
(2R)-2-[(2S,3S)-3-{(1R)-1-(t-butyldimethylsilyloxy)ethyl}-4-oxoazetidin-2-yl]propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / CAN / H₂O; acetonitrile / 1.5 h / 0 °C

2: 99 percent / imidazole / dimethylformamide / 14 h / Ambient temperature

3: 100 percent / H₂ / 5percent Pd-C / ethyl acetate / 20 h / Ambient temperature

4: 91 percent / pyridinium dichromate / dimethylformamide / 15 h / Ambient temperature

With 1H-imidazole; dipyridinium dichromate; ammonium cerium(IV) nitrate; hydrogen; palladium on activated charcoal; In water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(01)81722-1