Benzo[1,3]dioxol-5-ylmethyl-[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-amine

Base Information

• Chemical Name: Benzo[1,3]dioxol-5-ylmethyl-[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-amine
• CAS No.: 144836-41-9
• Molecular Formula: C₂₂H₁₈ClN₃O₂
• Molecular Weight: 391.857

Synonyms:Benzo[1,3]dioxol-5-ylmethyl-[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-amine

Chemical Property of Benzo[1,3]dioxol-5-ylmethyl-[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-amine

Chemical Property:

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Technology Process of Benzo[1,3]dioxol-5-ylmethyl-[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-amine

There total 3 articles about Benzo[1,3]dioxol-5-ylmethyl-[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-amine (144836-29-3) → Benzo[1,3]dioxol-5-ylmethyl-[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-amine (144836-41-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; 1.) 0 deg C, 1 h, 2.) RT, 3 h;

DOI:10.1016/0223-5234(92)90153-R

Reference yield:

piperonal (120-57-0,30024-74-9) → Benzo[1,3]dioxol-5-ylmethyl-[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-amine (144836-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / toluene / 17 h / Heating

2: 74 percent / NaBH₄ / methanol / 1.) 0 deg C, 1 h, 2.) RT, 3 h

With sodium tetrahydroborate; In methanol; toluene;

DOI:10.1016/0223-5234(92)90153-R

Reference yield:

1-(4-chlorophenyl)methyl-2-aminobenzimidazole (109635-38-3) → Benzo[1,3]dioxol-5-ylmethyl-[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-amine (144836-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / toluene / 17 h / Heating

2: 74 percent / NaBH₄ / methanol / 1.) 0 deg C, 1 h, 2.) RT, 3 h

With sodium tetrahydroborate; In methanol; toluene;

DOI:10.1016/0223-5234(92)90153-R

upstream raw materials:

[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-[1-(4-chloro-benzyl)-1H-benzoimidazol-2-yl]-amine

piperonal

1-(4-chlorophenyl)methyl-2-aminobenzimidazole

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