4-AMINO-3,5-DI-2-PYRIDYL-4H-1,2,4-TRIAZOLE

Base Information

• Chemical Name: 4-AMINO-3,5-DI-2-PYRIDYL-4H-1,2,4-TRIAZOLE
• CAS No.: 1671-88-1
• Molecular Formula: C12H10 N6
• Molecular Weight: 238.252
• Hs Code.: 2933990090
• Mol file: 1671-88-1.mol

Synonyms:Pyridine,2,2'-(4-amino-4H-1,2,4-triazole-3,5-diyl)di- (7CI,8CI);3,5-Bis(pyridin-2-yl)-4-amino-1,2,4-triazole; 4-Amino-3,5-bis(2-pyridyl)-4H-1,2,4-triazole;4-Amino-3,5-bis(2-pyridyl)1,2,4-triazole;4-Amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole;4-Amino-3,5-di(2-pyridyl)-1,2,4-triazole;4-Amino-3,5-di-2-pyridyl-4H-1,2,4-triazole

Chemical Property of 4-AMINO-3,5-DI-2-PYRIDYL-4H-1,2,4-TRIAZOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 182-184 °C(lit.)
• Refractive Index: 1.755
• Boiling Point: 536.352°C at 760 mmHg
• PKA: 0.56±0.10(Predicted)
• Flash Point: 278.176°C
• PSA: 82.51000
• Density: 1.429g/cm³
• LogP: 1.69710

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Amino-3,5-di-2-pyridyl-4H-1,2,4-triazole 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-3,5-DI-2-PYRIDYL-4H-1,2,4-TRIAZOLE

There total 4 articles about 4-AMINO-3,5-DI-2-PYRIDYL-4H-1,2,4-TRIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Cyanopyridine (100-70-9,1232006-36-8) → 4-amino-3,5-di-2-pyridyl-4H-1,2,4-triazole (1671-88-1)

Guidance literature:

With hydrazine dihydrochloride; hydrazine hydrate; In ethylene glycol; at 130 ℃; for 0.0833333h; microwave irradiation;

DOI:10.1016/S0040-4039(99)02350-3

Reference yield: 84.0%

3,6-di(pyridin-2-yl)-1,4-dihydro-1,2,4,5-tetrazine (1671-86-9) → 4-amino-3,5-di-2-pyridyl-4H-1,2,4-triazole (1671-88-1)

Guidance literature:

In hydrogenchloride; for 0.5h; Heating;

DOI:10.1002/ejic.200500972

Reference yield:

3,6-bis(2-pyridyl)-1,2-dihydro-1,2,4,5-tetrazine (1671-86-9) → 4-amino-3,5-di-2-pyridyl-4H-1,2,4-triazole (1671-88-1)

Guidance literature:

Acidic conditions;

DOI:10.1039/c9ce01871a

upstream raw materials:

2-Cyanopyridine

3,6-di(pyridin-2-yl)-1,4-dihydro-1,2,4,5-tetrazine

3,6-bis(2-pyridyl)-1,2-dihydro-1,2,4,5-tetrazine

Downstream raw materials:

3,5-bis(2-pyridyl)-4-hydro-1,2,4-triazole

[carbonyl-triphenylphosphino-(4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole)-rhodium] perchlorate

Refernces

• 1、 Muley, Arabinda,Karumban, Kalai Selvan,Gupta, Parth,Kumbhakar, Sadananda,Giri, Bishnubasu,Raut, Rajnikant,Misra, Ashish,Maji, Somnath. "Synthesis, structure, spectral, redox properties and anti-cancer activity of Ruthenium(II) Arene complexes with substituted Triazole Ligands". . . Retrieved 2021.
• 2、 White, Nicholas G.,Kitchen, Jonathan A.,Brooker, Sally. "A structural investigation of anion-triazole interactions: Observation of "π-pockets" and "jr-Sandwiches"". . p. 1172 - 1180. Retrieved 2009.
• 3、 Giri, Bishnubasu,Karumban, Kalai Selvan,Kumbhakar, Sadananda,Maji, Somnath,Muley, Arabinda. "High phenoxazinone synthase activity of two mononuclear: Cis -dichloro cobalt(ii) complexes with a rigid pyridyl scaffold". . p. 521 - 532. Retrieved 2022/01/22.