Chemical Property of 1H-Indole-5-carboxamide
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:159-163 °C
- Refractive Index:1.717
- Boiling Point:457.624 °C at 760 mmHg
- PKA:16.25±0.30(Predicted)
- Flash Point:230.563 °C
- PSA：58.88000
- Density:1.328 g/cm3
- LogP:1.96710
- Storage Temp.:2-8°C
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- XLogP3:0.9
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:1
- Exact Mass:160.063662883
- Heavy Atom Count:12
- Complexity:193
- Purity/Quality:
-
97% *data from raw suppliers
1H-Indole-5-carboxamide *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22-36/37/38
- Safety Statements:
26
- MSDS Files:
-
Useful:
- Canonical SMILES:C1=CC2=C(C=CN2)C=C1C(=O)N
-
Uses
1H-Indole-5-carboxamide (SD-169) is a p38α MAPK-selective inhibitor. 1H-Indole-5-carboxamide (SD-169) prevents the development and progression of diabetes in nonobese diabetic (NOD) mice by inhibiting
T cell infiltration and activation. SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM). It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM. SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg. In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis. SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage. 1H-Indole-5-carboxamide (SD-169) is a p38α MAPK-selective inhibitor. 1H-Indole-5-carboxamide (SD-169) prevents the development and progression of diabetes in nonobese diabetic (NOD) mice by inhibiting T cell infiltration and activation.
