L-4-(3-(benzyloxycarbonyl)-5-oxo-1,3-oxazolidin-4-yl)butanal

Base Information

• Chemical Name: L-4-(3-(benzyloxycarbonyl)-5-oxo-1,3-oxazolidin-4-yl)butanal
• CAS No.: 257638-95-2
• Molecular Formula: C₁₅H₁₇NO₅
• Molecular Weight: 291.304
• Mol file: 257638-95-2.mol

Synonyms:L-4-(3-(benzyloxycarbonyl)-5-oxo-1,3-oxazolidin-4-yl)butanal

Chemical Property of L-4-(3-(benzyloxycarbonyl)-5-oxo-1,3-oxazolidin-4-yl)butanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-4-(3-(benzyloxycarbonyl)-5-oxo-1,3-oxazolidin-4-yl)butanal

There total 3 articles about L-4-(3-(benzyloxycarbonyl)-5-oxo-1,3-oxazolidin-4-yl)butanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4S)-4-[3-(chloroformyl)propyl]-3-[(phenylmethoxy)carbonyl]oxazolidin-5-one (257638-94-1) → L-4-(3-(benzyloxycarbonyl)-5-oxo-1,3-oxazolidin-4-yl)butanal (257638-95-2)

Guidance literature:

With lithium tri(t-butoxy)aluminum hydride; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

L-3-(benzyloxycarbonyl)-4-(4-hydroxybutyl)-1,3-oxazolidin-5-one (141408-58-4) → L-4-(3-(benzyloxycarbonyl)-5-oxo-1,3-oxazolidin-4-yl)butanal (257638-95-2)

Guidance literature:

With sodium hydrogencarbonate; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1021/jm011063a

Reference yield:

(2S)-2-[(phenylmethoxy)carbonyl]aminoadipic acid (24325-14-2) → L-4-(3-(benzyloxycarbonyl)-5-oxo-1,3-oxazolidin-4-yl)butanal (257638-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 4.45 g / p-TsOH*H₂O / benzene / 18 h / Heating

2: Me₂S*BH₃ / tetrahydrofuran / 0 - 20 °C

3: PCC; NaHCO₃ / CH₂Cl₂ / 5 h / 20 °C

With dimethylsulfide borane complex; sodium hydrogencarbonate; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; benzene;

DOI:10.1021/jm011063a

upstream raw materials:

L-3-(benzyloxycarbonyl)-4-(4-hydroxybutyl)-1,3-oxazolidin-5-one

(2S)-2-[(phenylmethoxy)carbonyl]aminoadipic acid

(4S)-4-[3-(chloroformyl)propyl]-3-[(phenylmethoxy)carbonyl]oxazolidin-5-one

Downstream raw materials:

L-3-(benzyloxycarbonyl)-4-(4,4-dimethoxybutyl)-1,3-oxazolidin-5-one