1-(cyclopropylmethyl)-2-(2-isopropyl-1-(3-(2-methyl-1H-imidazol-1-yl)propyl)-5-phenyl-1H-pyrrol-3-yl)-1H-benzo[d]imidazole

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Chemical Name:1-(cyclopropylmethyl)-2-(2-isopropyl-1-(3-(2-methyl-1H-imidazol-1-yl)propyl)-5-phenyl-1H-pyrrol-3-yl)-1H-benzo[d]imidazole
CAS No.:1613405-08-5
Molecular Formula:C₃₁H₃₅N₅
Molecular Weight:477.652
Hs Code.:

Synonyms:1-(cyclopropylmethyl)-2-(2-isopropyl-1-(3-(2-methyl-1H-imidazol-1-yl)propyl)-5-phenyl-1H-pyrrol-3-yl)-1H-benzo[d]imidazole

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Chemical Property of 1-(cyclopropylmethyl)-2-(2-isopropyl-1-(3-(2-methyl-1H-imidazol-1-yl)propyl)-5-phenyl-1H-pyrrol-3-yl)-1H-benzo[d]imidazole

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Technology Process of 1-(cyclopropylmethyl)-2-(2-isopropyl-1-(3-(2-methyl-1H-imidazol-1-yl)propyl)-5-phenyl-1H-pyrrol-3-yl)-1H-benzo[d]imidazole

There total 5 articles about 1-(cyclopropylmethyl)-2-(2-isopropyl-1-(3-(2-methyl-1H-imidazol-1-yl)propyl)-5-phenyl-1H-pyrrol-3-yl)-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 33574-02-6
cyclopropylmethyl iodide

: 1613405-06-3
2-[2-isopropyl-1-(3-(2-methyl-1H-imidazol-1-yl)propyl)-5-phenyl-1H-pyrrol-3-yl]-1H-benzo[d]imidazole

: 1613405-08-5
1-(cyclopropylmethyl)-2-(2-isopropyl-1-(3-(2-methyl-1H-imidazol-1-yl)propyl)-5-phenyl-1H-pyrrol-3-yl)-1H-benzo[d]imidazole

Guidance literature:: With caesium carbonate; In acetonitrile; at 20 - 50 ℃; for 24h;
DOI:10.1021/jm500632s

Reference yield:

: 1613405-04-1
(E)-3-(1H-benzo[d]imidazol-2-yl)-1-phenylprop-2-en-1-one

: 1613405-08-5
1-(cyclopropylmethyl)-2-(2-isopropyl-1-(3-(2-methyl-1H-imidazol-1-yl)propyl)-5-phenyl-1H-pyrrol-3-yl)-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / ethanol / 70 °C

2: acetic acid / toluene / 3 h / 100 °C / Microwave irradiation

3: caesium carbonate / acetonitrile / 24 h / 20 - 50 °C

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; caesium carbonate; acetic acid; triethylamine; In ethanol; toluene; acetonitrile; 1: |Stetter 1,4-Dicarbonyl Synthesis / 2: |Paal-Knorr Pyrrole Synthesis;
DOI:10.1021/jm500632s

Reference yield:

: 3314-30-5
1H-benzoimidazole-2-carboxaldehyde

: 1613405-08-5
1-(cyclopropylmethyl)-2-(2-isopropyl-1-(3-(2-methyl-1H-imidazol-1-yl)propyl)-5-phenyl-1H-pyrrol-3-yl)-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 60 °C

2: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / ethanol / 70 °C

3: acetic acid / toluene / 3 h / 100 °C / Microwave irradiation

4: caesium carbonate / acetonitrile / 24 h / 20 - 50 °C

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; caesium carbonate; acetic acid; triethylamine; In ethanol; N,N-dimethyl-formamide; toluene; acetonitrile; 1: |Wittig Olefination / 2: |Stetter 1,4-Dicarbonyl Synthesis / 3: |Paal-Knorr Pyrrole Synthesis;
DOI:10.1021/jm500632s