(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-(1-(2-methyl-1-oxopropan-2-yl)-1H-imidazol-4-yl)pentanamide

Base Information

• Chemical Name: (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-(1-(2-methyl-1-oxopropan-2-yl)-1H-imidazol-4-yl)pentanamide
• CAS No.: 930100-79-1
• Molecular Formula: C₂₀H₂₄F₂N₄O₃
• Molecular Weight: 406.432
• Mol file: 930100-79-1.mol

Synonyms:(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-(1-(2-methyl-1-oxopropan-2-yl)-1H-imidazol-4-yl)pentanamide

Chemical Property of (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-(1-(2-methyl-1-oxopropan-2-yl)-1H-imidazol-4-yl)pentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-(1-(2-methyl-1-oxopropan-2-yl)-1H-imidazol-4-yl)pentanamide

There total 7 articles about (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-(1-(2-methyl-1-oxopropan-2-yl)-1H-imidazol-4-yl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H26F2N4O4 (1309885-15-1) → (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-(1-(2-methyl-1-oxopropan-2-yl)-1H-imidazol-4-yl)pentanamide (930100-79-1)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -30 ℃;

DOI:10.1016/j.bmcl.2010.12.117

Reference yield:

2-methyl-2-(4-nitroimidazol-1-yl)propionic acid methyl ester (865774-07-8) → (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-(1-(2-methyl-1-oxopropan-2-yl)-1H-imidazol-4-yl)pentanamide (930100-79-1)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr

2: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

3: diisobutylaluminium hydride / dichloromethane / -30 °C

With palladium 10% on activated carbon; hydrogen; diisobutylaluminium hydride; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.12.117

Reference yield:

2-(4-aminoimidazol-1-yl)-2-methylpropionic acid methyl ester (865775-54-8) → (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-(1-(2-methyl-1-oxopropan-2-yl)-1H-imidazol-4-yl)pentanamide (930100-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: diisobutylaluminium hydride / dichloromethane / -30 °C

With diisobutylaluminium hydride; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.12.117

upstream raw materials:

C₁₃H₁₅F₂NO₃

2-methyl-2-(4-nitroimidazol-1-yl)propionic acid methyl ester

C₁₈H₃₀N₄O₅

C₁₃H₂₂N₄O₃

Downstream raw materials:

C₂₄H₃₃F₂N₅O₃

C₂₁H₂₉F₂N₅O₂

C₂₃H₃₃F₂N₅O₂

C₂₆H₃₇F₂N₅O₃